PLCB3

Gene Symbol PLCB3
Entrez Gene 5331
Alt Symbol -
Species Human
Gene Type protein-coding
Description phospholipase C, beta 3 (phosphatidylinositol-specific)
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3|PLC beta 3|PLC-beta-3|phosphoinositide phospholipase C-beta-3
Swissprots G5E960 A5PKZ6 Q8N1A4 Q01970
Accessions AAA77683 CAA85776 CBF62886 CBF74559 CBU87762 CBU96709 EAW74230 EAW74231 Q01970 AB385031 BAG10887 BC032659 AAH32659 BC041625 BC142681 AAI42682 BC146645 Z16411 CAA78903 Z26649 XM_005274052 XP_005274109 XM_011545101 XP_011543403 NM_000932 NP_000923 NM_001184883 NP_001171812
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Location Membrane; Peripheral membrane protein.
Top Pathways Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Estrogen signaling pathway, Inflammatory mediator regulation of TRP channels

Phospho-PLCbeta3 (Ser1105) Antibody - 2484 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or PMA-treated for the indicated times, using Phospho-PLCbeta3 (Ser1105) Antibody (upper) or PLCbeta3 Antibody #2482 (lower).

Phospho-PLCbeta3 (Ser537) Antibody - 2481 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells treated with anisomycin (20 micrograms/ml) for 0, 15, 30 and 45 minutes, using Phospho-PLCbeta3 (Ser537) Antibody.

PLCbeta3 (D9D6S) Rabbit mAb - 14247 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9D6S
Western blot analysis of extracts from various cell lines using PLCbeta3 (D9D6S) Rabbit mAb.

PLCbeta3 Antibody - 2482 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or PMA-treated for the indicated times, using PLCbeta3 Antibody.

PLC β3 (C-20) - sc-403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLC β3 (C-20): sc-403. Western blot analysis of PLC β3 expression in SK-BR-3 (A), MCF7 (B), U-937 (C), CHO-K1 (D), A-431 (E), NIH/3T3 (F) and KNRK (G) whole cell lysates.

PLC β3 (D-7) - sc-133231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLC β3 (D-7): sc-133231. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic and membrane staining of glandular cells.

PLC β3 (H-3) - sc-133140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLC β3 (H-3): sc-133140. Western blot analysis of PLC β3 expression in non-transfected: sc-117752 (A) and human PLC β3 transfected: sc-112691 (B) 293T whole cell lysates.

PLC β3 (H-84) - sc-13958 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLC β3 (H-84): sc-13958. Western blot analysis of PLC β3 expression in A-431 (A), MCF7 (B), U-937 (C), NIH/3T3 (D) and KNRK (E) whole cell lysates.

PLC β3 (I-20) - sc-31761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLC β3 (I-20): sc-31761. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

PLC β3 (L-17) - sc-31760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLC β3 (L-17): sc-31760. Western blot analysis of PLC β3 expression in non-transfected: sc-117752 (A) and mouse PLC β3 transfected: sc-122623 (B) 293T whole cell lysates.

p-PLC β3 (Ser 537) - sc-34392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-PLC β3 (Ser 537): sc-34392. Western blot analysis of PLC β3 phosphorylation in non-transfected: sc-117752 (A) and human PLC β3 transfected: sc-112691 (B) 293T whole cell lysates.

Anti-Phospholipase C beta 3 (phospho S1105) antibody - ab52206 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human brain tissue stained with ab52206 at a dilution of 1/50 - 1/100. Right hand image: tissue treated with immunising peptide; left hand image: untreated.

Anti-Phospholipase C beta 3 (phospho S537) antibody - ab73998 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab73998 stained HCT116 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab73998, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-Phospholipase C beta 3 (phospho S537) antibody [EPR1498Y] - ab51247 from Abcam

Prices $99.00, $313.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1498Y
All lanes : Anti-Phospholipase C beta 3 (phospho S537) antibody [EPR1498Y] (ab51247) at 1/2000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate, treated with TPALysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-Phospholipase C beta 3 antibody - ab52199 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Paraffin-embedded human brain tissue stained for phospholipase C beta 3, using ab52199 (1/100). The right hand panel represents a negative control in which ab52199 has been pre-incubated with the immunizing (blocking) peptide.

Anti-Phospholipase C beta 3 antibody - ab63627 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using ab63627 at a dilution of 1/50-1/100. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-Phospholipase C beta 3 antibody [EPR5951] - ab124735 from Abcam

Prices $99.00, $385.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5951
All lanes : Anti-Phospholipase C beta 3 antibody [EPR5951] (ab124735) at 1/1000 dilutionLane 1 : HCT 116 cell lysateLane 2 : 293T cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-PLCB3 Antibody (phospho-Ser537) - LS-C9590 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCB3 Antibody (phospho-Ser1105, clone EPR1498Y) - LS-C49973 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1498Y
Western blot analysis on HeLa cell lysates using anti-Phospho-PLCB3 (pS357) antibody, 1:2000 dilution. Cells were either (A) untreated or (B) treated with TPA.

Anti-PLCB3 Antibody (phospho-Ser537) - LS-C313628 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLCB3 Antibody (aa1071-1120) - LS-C117570 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, treated with PMA 125 ng/ml 30', using PLCB3 (Ab-1105) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PLCB3 Antibody (Leu532) - LS-C176630 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of PLC 3 (L532) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-PLCB3 Antibody (phospho-Ser537) - LS-C199471 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using PLC beta3 (Phospho-Ser537) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-PLCB3 Antibody (phospho-Ser1105) - LS-C199472 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using PLCB3 (Phospho-Ser1105) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-PLCB3 Antibody (Asp1099) - LS-C176571 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of PLC 3 (D1099) pAb in paraffin-embedded human brain tissue.
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