Aimp1

Gene Symbol Aimp1
Entrez Gene 13722
Alt Symbol 9830137A06Rik, AIMP1/p43, EMAPII, Emap2, Scye1, p43
Species Mouse
Gene Type protein-coding
Description aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Other Description ARS inducible multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte activating polypeptide 2|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1
Swissprots P31230 Q60659
Accessions EDL12194 P31230 AK036573 AK050571 AK087932 BAC40045 AK133859 BAE21893 AK160506 BAE35830 BC002054 AAH02054 BY256548 BY631162 U10118 AAA62203 NM_007926 NP_031952
Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels. Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
Tissue Specificity Highly expressed in salivary glands and pancreatic alpha cells in the adult (at protein level). In the embryo, expressed primarily at sites of tissue remodeling such as ganglia, developing bones and teeth. {ECO:0000269|PubMed:17001013, ECO:0000269|PubMed:9770485}.

Recombinant Mouse Pro-EMAP-II, CF - 2026-EM-050 from R&D Systems

Category Protein
Source E. coli-derived, Ala2-Lys310, with an N-terminal Met and 6-His tag

Recombinant Mouse Aimp1, None tagged - Aimp1-7399M from Creative Biomart

Category Protein
Source E. coli
Species Mouse

Aimp1 - PN201205 from Elabscience

Category Protein
Prices $225.00, $475.00
Sizes 10 μg, 50 μg
Source E.coli
Species Mouse

Mouse AIMP1 / EMAP2 / SCYE1 Protein - 50697-MNAE-50 from Sino Biological

Category Protein
Source E. coli
Species Mouse

Recombinant Mouse Pro-EMAP-II Protein, CF - 2026-EM from R&D Systems

Category Protein
Prices $329.00
Sizes 50 µg
Source E. coli -derived Ala2-Lys310, with an N-terminal Met and 6-His tag
Species Mouse

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Aimp1) , Recombinant Protein - MBS1010362 from MyBioSource

Category Protein
Prices $1,670.00, $1,670.00, $2,135.00, $2,135.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

AIMP1 Recombinant Protein (OPCD01225) - OPCD01225 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Mouse AIMP1 / EMAP2 / SCYE1 Protein - 50697-MNAE from ABclonal

Category Protein
Prices $178.00, $298.00
Sizes 50 µg, 100 µg
Source E. coli
Species Mouse

Recombinant Mouse Aminoacyl tRNA synthase complex-interacting multifunctional protein 1(Aimp1) - AP74532 from Signalway Antibody

Category Protein
Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg
Source E.coli
Species Mouse

AIMP1 Recombinant Protein (Mouse) (OPCA04302) - OPCA04302 from Aviva Systems Biology

Category Protein
Species Mouse

Mouse Aimp1 protein - orb383109 from Biorbyt

Category Protein
Species Mouse
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