| Gene Symbol |
Aimp1
|
| Entrez Gene |
13722
|
| Alt Symbol |
9830137A06Rik, AIMP1/p43, EMAPII, Emap2, Scye1, p43
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
|
| Other Description |
ARS inducible multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte activating polypeptide 2|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1
|
| Swissprots |
P31230 Q60659
|
| Accessions |
EDL12194 P31230 AK036573 AK050571 AK087932 BAC40045 AK133859 BAE21893 AK160506 BAE35830 BC002054 AAH02054 BY256548 BY631162 U10118 AAA62203 NM_007926 NP_031952
|
| Function |
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels. Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
|
| Tissue Specificity |
Highly expressed in salivary glands and pancreatic alpha cells in the adult (at protein level). In the embryo, expressed primarily at sites of tissue remodeling such as ganglia, developing bones and teeth. {ECO:0000269|PubMed:17001013, ECO:0000269|PubMed:9770485}.
|