Gene Symbol | HECTD3 |
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Entrez Gene | 79654 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | HECT domain containing E3 ubiquitin protein ligase 3 |
Other Description | E3 ubiquitin-protein ligase HECTD3 |
Swissprots | Q5T447 B3KRH4 Q9H783 Q5T448 B3KPV7 |
Accessions | EAX07009 EAX07010 Q5T447 AA001245 AK056545 BAG51742 AK056873 BAG51819 AK091583 BAG52386 AK096462 BAG53296 AK301124 BAG62718 AW170440 BC012829 BC019105 AAH19105 BC126352 AAI26353 BC130470 AAI30471 BQ215795 CA314393 DA332198 XM_011542140 XP_011540442 NM_024602 NP_078878 |
Function | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. |
HECTD3 CRISPR/Cas9 KO Plasmid (h) - sc-406532 from Santa Cruz Biotechnology
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HECTD3 HDR Plasmid (h) - sc-406532-HDR from Santa Cruz Biotechnology
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HECTD3 Double Nickase Plasmid (h) - sc-406532-NIC from Santa Cruz Biotechnology
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HECTD3 Double Nickase Plasmid (h2) - sc-406532-NIC-2 from Santa Cruz Biotechnology
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HECTD3 CRISPR Activation Plasmid (h) - sc-406532-ACT from Santa Cruz Biotechnology
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HECTD3 CRISPR Activation Plasmid (h2) - sc-406532-ACT-2 from Santa Cruz Biotechnology
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HECTD3 Lentiviral Activation Particles (h) - sc-406532-LAC from Santa Cruz Biotechnology
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HECTD3 Lentiviral Activation Particles (h2) - sc-406532-LAC-2 from Santa Cruz Biotechnology
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HECTD3 siRNA (h) - sc-78623 from Santa Cruz Biotechnology
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HECTD3 shRNA Plasmid (h) - sc-78623-SH from Santa Cruz Biotechnology
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HECTD3 shRNA (h) Lentiviral Particles - sc-78623-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9961 from Sigma-Aldrich
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HECTD3 siRNA (Human) - CRJ2460 from Cohesion Biosciences
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HECTD3 - MBS8236777 from MyBioSource
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shRNA set against Human HECTD3 (NM_024602.5) - SHH311389 from Creative biogene
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shRNA set against Human HECTD3(NM_024602.5) - SHH117821 from Creative biogene
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Human HECTD3 siRNA - orb272961 from Biorbyt
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HECTD3 shRNA Plasmid (Human) - CHJ2460 from Cohesion Biosciences
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HECTD3 miRNA 3'UTR clone - MiUTR1H-04450 from Creative biogene
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