| Gene Symbol |
HECTD3
|
| Entrez Gene |
79654
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT domain containing E3 ubiquitin protein ligase 3
|
| Other Description |
E3 ubiquitin-protein ligase HECTD3
|
| Swissprots |
Q5T447 B3KRH4 Q9H783 Q5T448 B3KPV7
|
| Accessions |
EAX07009 EAX07010 Q5T447 AA001245 AK056545 BAG51742 AK056873 BAG51819 AK091583 BAG52386 AK096462 BAG53296 AK301124 BAG62718 AW170440 BC012829 BC019105 AAH19105 BC126352 AAI26353 BC130470 AAI30471 BQ215795 CA314393 DA332198 XM_011542140 XP_011540442 NM_024602 NP_078878
|
| Function |
E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000250}.
|
![Western Blot: HECTD3 Overexpression Lysate (Adult Normal) [NBL1-11500] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HECTD3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3080_HECTD3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11500-img0002.jpg)