Gene Symbol | MINPP1 |
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Entrez Gene | 9562 |
Alt Symbol | HIPER1, MINPP2, MIPP |
Species | Human |
Gene Type | protein-coding |
Description | multiple inositol-polyphosphate phosphatase 1 |
Other Description | 2,3-BPG phosphatase|2,3-bisphosphoglycerate 3-phosphatase|inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase|ins(1,3,4,5)P(4) 3-phosphatase|multiple inositol polyphosphate histidine phosphatase, 1|multiple inositol polyphosphate phosphatase 1|multiple inositol polyphosphate phosphatase 2 |
Swissprots | Q9UNW1 Q59EJ2 O95172 O95286 Q9UGA3 F5H683 |
Accessions | AAD02438 EAW50185 EAW50186 Q9UNW1 AB209819 BAD93056 AF046914 AAD02437 AF084943 AAD09751 AF084944 AAD09752 AK304624 BAG65406 AK309176 AK312937 BAG35779 AL050356 CAB43673 AW243689 AY358938 AAQ89297 BC032504 AAH32504 BU173009 DA295586 HQ447272 ADQ31759 XM_006718078 XP_006718141 XM_011540379 XP_011538681 XR_945884 NM_001178117 NP_001171588 NM_001178118 NP_001171589 NM_004897 NP_004888 |
Function | Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). {ECO:0000269|PubMed:18413611}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. |
Tissue Specificity | Widely expressed with highest levels in kidney, liver and placenta. {ECO:0000269|PubMed:9923613}. |
Top Pathways | Glycolysis / Gluconeogenesis, Inositol phosphate metabolism |
MIPP CRISPR/Cas9 KO Plasmid (h) - sc-407410 from Santa Cruz Biotechnology
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MIPP HDR Plasmid (h) - sc-407410-HDR from Santa Cruz Biotechnology
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MIPP Double Nickase Plasmid (h) - sc-407410-NIC from Santa Cruz Biotechnology
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MIPP Double Nickase Plasmid (h2) - sc-407410-NIC-2 from Santa Cruz Biotechnology
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MIPP CRISPR Activation Plasmid (h) - sc-407410-ACT from Santa Cruz Biotechnology
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MIPP CRISPR Activation Plasmid (h2) - sc-407410-ACT-2 from Santa Cruz Biotechnology
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MIPP Lentiviral Activation Particles (h) - sc-407410-LAC from Santa Cruz Biotechnology
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MIPP Lentiviral Activation Particles (h2) - sc-407410-LAC-2 from Santa Cruz Biotechnology
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MIPP siRNA (h) - sc-106226 from Santa Cruz Biotechnology
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MIPP shRNA Plasmid (h) - sc-106226-SH from Santa Cruz Biotechnology
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MIPP shRNA (h) Lentiviral Particles - sc-106226-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU064791 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0315 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0313 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0314 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13334 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13334 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07026 from Sigma-Aldrich
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MINPP1 siRNA (Human) - CRH6361 from Cohesion Biosciences
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MINPP1 RNAi - H00009562-R01 from Novus Biologicals
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shRNA set against Human MINPP1 (NM_004897.4) - SHH342055 from Creative biogene
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Human MINPP1 siRNA - orb266863 from Biorbyt
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MINPP1 shRNA Plasmid (Human) - CHH6361 from Cohesion Biosciences
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MINPP1 miRNA 3'UTR clone - MiUTR3H-07624 from Creative biogene
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