Gene Symbol | MINPP1 |
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Entrez Gene | 9562 |
Alt Symbol | HIPER1, MINPP2, MIPP |
Species | Human |
Gene Type | protein-coding |
Description | multiple inositol-polyphosphate phosphatase 1 |
Other Description | 2,3-BPG phosphatase|2,3-bisphosphoglycerate 3-phosphatase|inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase|ins(1,3,4,5)P(4) 3-phosphatase|multiple inositol polyphosphate histidine phosphatase, 1|multiple inositol polyphosphate phosphatase 1|multiple inositol polyphosphate phosphatase 2 |
Swissprots | Q9UNW1 Q59EJ2 O95172 O95286 Q9UGA3 F5H683 |
Accessions | AAD02438 EAW50185 EAW50186 Q9UNW1 AB209819 BAD93056 AF046914 AAD02437 AF084943 AAD09751 AF084944 AAD09752 AK304624 BAG65406 AK309176 AK312937 BAG35779 AL050356 CAB43673 AW243689 AY358938 AAQ89297 BC032504 AAH32504 BU173009 DA295586 HQ447272 ADQ31759 XM_006718078 XP_006718141 XM_011540379 XP_011538681 XR_945884 NM_001178117 NP_001171588 NM_001178118 NP_001171589 NM_004897 NP_004888 |
Function | Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). {ECO:0000269|PubMed:18413611}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. |
Tissue Specificity | Widely expressed with highest levels in kidney, liver and placenta. {ECO:0000269|PubMed:9923613}. |
Top Pathways | Glycolysis / Gluconeogenesis, Inositol phosphate metabolism |
Human MINPP1 protein fragment - ab160547 from Abcam
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MINPP1 Antibody Blocking Peptide - LS-E58 from LifeSpan Bioscience
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MINPP1 Antibody Blocking Peptide - LS-E3527 from LifeSpan Bioscience
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MINPP1 Antibody Blocking Peptide - LS-E24056 from LifeSpan Bioscience
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Recombinant Human MINPP1 Protein - H00009562-Q01 from Novus Biologicals
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MINPP1-Antibody-N-term-Blocking-peptide - BP10126a from Abgent, a WuXi AppTec company
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MINPP1-Antibody-C-term-Blocking-Peptide - BP14723b from Abgent, a WuXi AppTec company
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Human MINPP1 R protein - orb163364 from Biorbyt
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Human MINPP1 protein - orb244995 from Biorbyt
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Human MINPP1 protein - orb246205 from Biorbyt
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MINPP1 - H00009562-Q01-10 from Acris Antibodies
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MINPP1 - H00009562-Q01-25 from Acris Antibodies
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MINPP1 Control Peptide - AP10148CP-N from Acris Antibodies
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Recombinant Human MINPP1 Enzyme - BP001321-C525 from Syd Labs
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Recombinant Human MINPP1, His-tagged - MINPP1-142H from Creative Biomart
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MIPP (I360) Peptide - BS9152P from Bioworld Technology
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Recombinant human Multiple inositol polyphosphate phosphatase 1 - CSB-YP891977HU CSB-BP891977HU CSB-MP891977HU from Cusabio
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Recombinant human Multiple inositol polyphosphate phosphatase 1 - CSB-EP891977HU from Cusabio
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MINPP1 - TP307581 from Acris Antibodies
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MINPP1 (transcript variant 2) - TP329866 from Acris Antibodies
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MINPP1 (full length, C-term DDK tag, transcript variant 1) - TP710176 from Acris Antibodies
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MINPP1 (transcript variant 1) - TP720678 from Acris Antibodies
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MINPP1 Blocking Peptide - abx061303 from Abbexa
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MINPP1 Recombinant Protein Antigen - NBP1-82644PEP from Novus Biologicals
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MINPP1 Peptide, Human - M34GP09527H from Creative Peptides
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