PMS2

Gene Symbol	PMS2
Entrez Gene	5395
Alt Symbol	HNPCC4, PMS2CL, PMSL2
Species	Human
Gene Type	protein-coding
Description	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Other Description	DNA mismatch repair protein PMS2|H_DJ0042M02.9|PMS1 protein homolog 2|mismatch repair endonuclease PMS2
Swissprots	P54278 B2R610 Q75MR2 Q5FBX2 Q5FBX1 Q52LH6 Q5FBW9
Accessions	AAA63923 AAS00390 ABQ59090 EAW55055 P54278 AB103082 BAD89425 AB103083 BAD89426 AB103085 BAD89428 AB103086 BAD89429 AB103087 BAD89430 AI433648 AK125607 AK294661 BAG57831 AK312390 BAG35307 BC008400 BC031832 BC093921 AAH93921 BC143397 BM669686 BP251389 BQ050630 BX537558 CAD97782 CR981250 DA774159 DB527312 U14658 AAA50390 XM_006715742 XP_006715805 XM_006715744 XP_006715807 XM_011515427 XP_011513729 XM_011515428 XP_011513730 XM_011515429 XP_011513731 XM_011515430 XP_011513732 NM_000535 NP_000526 NR_003085
Function	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in ca
Subcellular Location	Nucleus.
Top Pathways	Mismatch repair, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PMS2 full length protein - ab131836 from Abcam Category Protein Source Wheat germ Species Human

Human PMS2 full length protein - ab166543 from Abcam Category Protein Source Wheat germ Species Human

PMS2 Antibody Blocking Peptide - LS-E20320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PMS2 Protein - H00005395-Q01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PMS2 Protein - H00005395-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PMS2 Blocking Peptide - 33R-4074 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PMS2 Blocking Peptide - 33R-10768 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

PMS2 - H00005395-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PMS2 - H00005395-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PMS2 Control Peptide - AP00189CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PMS2 fusion protein - ag12651 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PMS2 fusion protein - Ag12661 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PMS2 (D483) Peptide - BS2688P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Mismatch repair endonuclease PMS2(PMS2) ,partial - CSB-YP018246HU CSB-EP018246HU CSB-BP018246HU CSB-MP018246HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PMS2 Blocking Peptide - 3455BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

PMS2 (transcript variant 1) - TP310880 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PMS2, Peptide - MBS843567 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

PMS2-Antibody-Center-Blocking-Peptide - BP7356c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PMS2-Antibody-C-term-Blocking-Peptide - BP7356b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PMS2 Peptide, Human - M34GP12012H from Creative Peptides Category Peptide Source Synthetic. Species Human

PMS2 Recombinant Protein Antigen - NBP2-56511PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PMS2 Recombinant Protein Antigen - NBP2-56323PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PMS2 Recombinant Protein Antigen - NBP2-58488PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

Mismatch repair endonuclease PMS2 (PMS2), partial, Recombinant Protein - MBS951339 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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