| Gene Symbol | BNIP3 |
|---|---|
| Entrez Gene | 664 |
| Alt Symbol | NIP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Other Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Swissprots | O14620 Q96GP0 Q12983 |
| Accessions | AAW62256 CAI45349 EAW49143 Q12983 AF002697 AAC16738 AK130264 AK222626 BAD96346 AK295136 BAG58159 BC009342 BC021989 AAH21989 BC067818 AAH67818 BC080643 AAH80643 BX647339 HQ448726 ADQ33204 HY049371 U15174 AAC00022 NM_004052 NP_004043 |
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}. |
| Subcellular Location | Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| Top Pathways | Legionellosis |
BNIP-3 CRISPR/Cas9 KO Plasmid (h) - sc-400985 from Santa Cruz Biotechnology
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BNIP-3 HDR Plasmid (h) - sc-400985-HDR from Santa Cruz Biotechnology
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BNIP-3 Double Nickase Plasmid (h) - sc-400985-NIC from Santa Cruz Biotechnology
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BNIP-3 Double Nickase Plasmid (h2) - sc-400985-NIC-2 from Santa Cruz Biotechnology
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BNIP-3 CRISPR Activation Plasmid (h) - sc-400985-ACT from Santa Cruz Biotechnology
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BNIP-3 CRISPR Activation Plasmid (h2) - sc-400985-ACT-2 from Santa Cruz Biotechnology
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BNIP-3 Lentiviral Activation Particles (h) - sc-400985-LAC from Santa Cruz Biotechnology
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BNIP-3 Lentiviral Activation Particles (h2) - sc-400985-LAC-2 from Santa Cruz Biotechnology
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BNIP-3 siRNA (h) - sc-37451 from Santa Cruz Biotechnology
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BNIP-3 shRNA Plasmid (h) - sc-37451-SH from Santa Cruz Biotechnology
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BNIP-3 shRNA (h) Lentiviral Particles - sc-37451-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU112661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4019 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06636 from Sigma-Aldrich
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BNIP3 siRNA (Human) - CRH0459 from Cohesion Biosciences
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BNIP3 - MBS8224452 from MyBioSource
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shRNA set against Human BNIP3 (NM_004052.2) - SHH247274 from Creative biogene
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shRNA set against Human BNIP3(NM_004052.2) - SHG102907 from Creative biogene
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BNIP3 shRNA Plasmid (Human) - CHH0459 from Cohesion Biosciences
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BNIP3 miRNA 3'UTR clone - MiUTR1H-00924 from Creative biogene
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