BNIP3

Gene Symbol	BNIP3
Entrez Gene	664
Alt Symbol	NIP3
Species	Human
Gene Type	protein-coding
Description	BCL2/adenovirus E1B 19kDa interacting protein 3
Other Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Swissprots	O14620 Q96GP0 Q12983
Accessions	AAW62256 CAI45349 EAW49143 Q12983 AF002697 AAC16738 AK130264 AK222626 BAD96346 AK295136 BAG58159 BC009342 BC021989 AAH21989 BC067818 AAH67818 BC080643 AAH80643 BX647339 HQ448726 ADQ33204 HY049371 U15174 AAC00022 NM_004052 NP_004043
Function	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
Subcellular Location	Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Top Pathways	Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BNIP3 peptide - ab32964 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

NIP3 / BNIP3 Antibody Blocking Peptide - LS-E2279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BNIP3-Antibody-BH3-Domain-Specific-Blocking-peptide - BP1321a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human BNIP3 protein - orb163514 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

BNIP3 peptide - orb216968 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

BNIP3 Blocking Peptide - abx062299 from Abbexa Category Peptide Species Human

Recombinant Human BNIP3, HEK293 Lysate - 230-10047-100 from RayBiotech Category Protein Prices $154.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

Recombinant Human BNIP3, HEK293 Transfected Cell Culture Supernatant - 230-20025-200 from RayBiotech Category Protein Prices $113.00 Sizes 200 µl Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

BNIP3, Human, Recombinant - 19-CF87 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

BNIP3 fusion protein - Ag19755 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

BNIP3 fusion protein - Ag19747 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

BNIP3 fusion protein - ag13207 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BNIP3 Protein - BP002631-CF87 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human BNIP3, His-tagged - BNIP3-10262H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) - RPJ545Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

BNIP3 Blocking Peptide - CBP1105 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

BNIP-3 (E96) Peptide - BS3545P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Human BNIP3, HEK293 Lysate - orb305084 from Biorbyt Category Protein Prices $298.00 Sizes 100 μg Species Human

BNIP3 Blocking Peptide - abx061122 from Abbexa Category Peptide Species Human, Mouse

BNIP3 Peptide, Human - M34GP01488H from Creative Peptides Category Peptide Source Synthetic. Species Human

BNIP3 Blocking Peptide - CBP5035 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Human BCL2/Adenovirus E1B 19 kDa interacting protein 3/BNIP3 - 230-00766-10 from RayBiotech Category Protein Prices $79.53 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

BNIP3 Recombinant Protein Antigen - NBP1-82566PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human BNIP3 protein - orb385080 from Biorbyt Category Protein Prices $374.00, $391.00, $527.00, $876.00 Sizes 10 μg, 50 μg, 100 μg, 250 μg Species Human

BNIP3 Recombinant Protein - 92-129 from ProSci Category Protein Prices $525.00 Sizes 50 µg Source E. coli Species Human

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