BNIP3

Gene Symbol	BNIP3
Entrez Gene	664
Alt Symbol	NIP3
Species	Human
Gene Type	protein-coding
Description	BCL2/adenovirus E1B 19kDa interacting protein 3
Other Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Swissprots	O14620 Q96GP0 Q12983
Accessions	AAW62256 CAI45349 EAW49143 Q12983 AF002697 AAC16738 AK130264 AK222626 BAD96346 AK295136 BAG58159 BC009342 BC021989 AAH21989 BC067818 AAH67818 BC080643 AAH80643 BX647339 HQ448726 ADQ33204 HY049371 U15174 AAC00022 NM_004052 NP_004043
Function	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
Subcellular Location	Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Top Pathways	Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat NIP3 / BNIP3 ELISA Kit (Sandwich ELISA) - LS-F6794 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.228 ng/ml Range 0.625-40 ng/ml

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), Human, ELISA Kit - E01B0819 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/ml

BCL2/adenovirus E1B 19kDa interacting protein 3, ELISA Kit - MBS9324001 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3), ELISA Kit - MBS2024250 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of rat BNIP3 is typically less than 0.228ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.625-40ng/mL

ELISA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) - SEJ545Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.228ng/mL. Range 0.625-40ng/mL The standard curve concentrations used for the ELISA’s were 40ng/mL, 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL

CLIA Kit for Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) - SCJ545Ra from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL. Range 0.055-40ng/mL The standard curve concentrations used for the CLIA’s were 40ng/mL, 13.333ng/mL, 4.444ng/mL, 1.481ng/mL, 0.494ng/mL, 0.165ng/mL, 0.055ng/mL

Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3), CLIA Kit - MBS2000625 from MyBioSource Category CLIA Kit Prices $470.00, $705.00, $970.00, $4,005.00, $7,215.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 0.03ng/mL. Range 0.055-40ng/mL

Rat NIP3 / BNIP3 ELISA Kit (CLIA) - LS-F26505 from LifeSpan Bioscience Category ELISA Kit Prices $1,010.00 Sizes 1 plate Sensitivity 0.03 ng/ml Range 0.625-40 ng/ml

Human BNIP3 ELISA Kit - E004578 from Biobool Category ELISA Kit

anti-BNIP3 antibody - ARG54833 from Arigo Biolaboratories Category ELISA Kit

BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3), ELISA Kit - MBS7606308 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.281ng/ml Range 0.469-30ng/ml

Bnip3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3), ELISA Kit - MBS7606766 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

BCL2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3), ELISA Kit - MBS9372805 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

BNIP3 ELISA Kit (Human) (OKWB00193) - OKWB00193 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.281 ng/mL Range 0.469 - 30 ng/mL

Human NIP3 / BNIP3 ELISA Kit (Sandwich ELISA) - LS-F31912 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.281 Range 0.625-40 ng/ml

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