APOBR

Gene Symbol APOBR
Entrez Gene 55911
Alt Symbol APOB100R, APOB48R
Species Human
Gene Type protein-coding
Description apolipoprotein B receptor
Other Description apoB-48R|apolipoprotein B-100 receptor|apolipoprotein B-48 receptor|apolipoprotein B100 receptor|apolipoprotein B48 receptor
Swissprots Q0VD81 H3BU97 Q0VD83 Q9NPJ9 Q8NC15
Accessions AAF76256 EAW52278 EAW52279 EAW52280 Q0VD83 AF141332 AAF76255 AF141334 AAF78765 AK025123 AK075085 BC119786 AAI19787 BC119788 AAI19789 NM_018690 NP_061160
Function Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:10852956, ECO:0000269|PubMed:15591219, ECO:0000269|PubMed:9633939}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}; Peripheral membrane protein {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
Tissue Specificity Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:10852956}.

apoB48R CRISPR/Cas9 KO Plasmid (h) - sc-412639 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R HDR Plasmid (h) - sc-412639-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R Double Nickase Plasmid (h) - sc-412639-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R Double Nickase Plasmid (h2) - sc-412639-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R CRISPR Activation Plasmid (h) - sc-412639-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R CRISPR Activation Plasmid (h2) - sc-412639-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R Lentiviral Activation Particles (h) - sc-412639-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R Lentiviral Activation Particles (h2) - sc-412639-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoB48R siRNA (h) - sc-93294 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

apoB48R shRNA Plasmid (h) - sc-93294-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

apoB48R shRNA (h) Lentiviral Particles - sc-93294-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APOB48R RNAi - H00055911-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

APOB48R RNAi - H00055911-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU000751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3331 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03945 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03945

APOBR siRNA (Human) - CRJ1009 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APOBR - MBS828858 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human APOBR (NM_018690.3) - SHH238474 from Creative biogene

Category siRNA
Species Reactivities Human

APOBR shRNA Plasmid (Human) - CHJ1009 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APOBR miRNA 3'UTR clone - MiUTR3H-07485 from Creative biogene

Species Reactivities Human
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