| Gene Symbol |
APOBR
|
| Entrez Gene |
55911
|
| Alt Symbol |
APOB100R, APOB48R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B receptor
|
| Other Description |
apoB-48R|apolipoprotein B-100 receptor|apolipoprotein B-48 receptor|apolipoprotein B100 receptor|apolipoprotein B48 receptor
|
| Swissprots |
Q0VD81 H3BU97 Q0VD83 Q9NPJ9 Q8NC15
|
| Accessions |
AAF76256 EAW52278 EAW52279 EAW52280 Q0VD83 AF141332 AAF76255 AF141334 AAF78765 AK025123 AK075085 BC119786 AAI19787 BC119788 AAI19789 NM_018690 NP_061160
|
| Function |
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:10852956, ECO:0000269|PubMed:15591219, ECO:0000269|PubMed:9633939}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}; Peripheral membrane protein {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:7619811}. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.
|
| Tissue Specificity |
Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. {ECO:0000269|PubMed:10191299, ECO:0000269|PubMed:10852956}.
|