TJP1

Gene Symbol TJP1
Entrez Gene 7082
Alt Symbol ZO-1
Species Human
Gene Type protein-coding
Description tight junction protein 1
Other Description tight junction protein ZO-1|zona occludens 1|zonula occludens 1 protein
Swissprots B4E3K1 Q2NKP3 Q07157 Q4ZGJ6
Accessions AAG43399 AAY22179 EAW51506 EAW51507 EAW51508 EAW51509 EAW51510 Q07157 AB370197 BAF95000 AF035298 AK302971 BAG64116 AK304758 BAG65513 AK308113 BC036090 BC111712 AAI11713 BX640879 CAE45936 CN372462 CR749235 CAH18091 DA752892 EU831947 ACE87388 EU832042 ACE86704 XM_005254617 XP_005254674 XM_005254618 XP_005254675 XM_005254619 XP_005254676 XM_005254620 XP_005254677 XM_005254621 XP_005254678 XM_006720660 XP_006720723 XM_006725554 XP_006725617 XM_006725555 XP_006725618 XM_006725556 XP_006725619 XM_006725557 XP_006725620 XM_006725558 XP_006725621 XM_006725560 XP_006725623 XM_011521972 XP_011520274 XM_011521973 XP_011520275 XM_011521974 XP_011520276 XM_011521975 XP_011520277 XM_011547422 XP_011545724 XM_011547423 XP_011545725 XM_011547424 XP_011545726 XM_011548946 XP_011547248 XM_011548947 XP_011547249 XM_011548948 XP_011547250 XM_011548949 XP_011547251 XM_011548950 XP_011547252 XM_011548951 XP_011547253 XM_011548952 XP_011547254 XM_011548953 XP_011547255 XM_011548954 XP_011547256 NM_001301025 NP_001287954 NM_001301026 NP_001287955 NM_003257 NP_003248 NM_175610 NP_783297
Function The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. {ECO:0000269|PubMed:21240187}.
Subcellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.
Tissue Specificity The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
Top Pathways Adherens junction, Tight junction, Gap junction, Epithelial cell signaling in Helicobacter pylori infection, Vibrio cholerae infection

ZO-1 Antibody - 5406 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using ZO-1 Antibody.

ZO-1 (D7D12) Rabbit mAb - 8193 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7D12
Western blot analysis of extracts from various cell lines using ZO-1 (D7D12) Rabbit mAb.

ZO-1 (C-19) - sc-8146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ZO-1 (C-19): sc-8146. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.

ZO-1 (H-300) - sc-10804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ZO-1 (H-300): sc-10804. Western blot analysis of ZO-1 expression in MDCK whole cell lysate.

ZO-1 (N-19) - sc-8147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ZO-1 (N-19): sc-8147. Western blot analysis of ZO-1 expression in rat testis extract.

Anti-ZO1 tight junction protein antibody - ab96594 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-ZO1 tight junction protein antibody (ab96594) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-ZO1 tight junction protein antibody - ab187012 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZO1 tight junction protein antibody - ab99462 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-ZO1 tight junction protein antibody (ab99462) at 0.3 µg/ml + Human brain (cerebral cortex) lysate at 35 µgdeveloped using the ECL technique

Anti-ZO1 tight junction protein antibody [mAbcam 61357] (FITC) - ab150266 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam 61357
Overlay histogram showing MCF7 cells stained with ab150266 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab150266, 0.1μg/1x106 cells) for 30 min at 22ºC.Isotype control antibody (black line) was mouse IgG1 [ICIG1] FITC (ab91356) used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-TJP1 / ZO-1 Antibody - LS-C18590 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TJP1 / ZO-1 Antibody (aa432-1150) - LS-C124819 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TJP1 / ZO-1 Antibody (aa866-995) - LS-C124820 from LifeSpan Bioscience

Prices $620.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TJP1 / ZO-1 Antibody (aa432-1150) - LS-C140250 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TJP1 / ZO-1 Antibody - LS-C124822 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-TJP1 / ZO-1 Antibody - LS-C140251 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Guinea Pig
Clonality Polyclonal

Anti-TJP1 / ZO-1 Antibody (aa1574-1748) - LS-C186003 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug whole cell lysate). A: H1299. 5% SDS PAGE. ZO-1 antibody diluted at 1:1000

Anti-TJP1 / ZO-1 Antibody (N-Terminus) - LS-C145545 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TJP1 / ZO-1 antibody LS-C145545 Western blot of Rat Lung lysate. Antibody concentration 1 ug/ml.

Anti-TJP1 / ZO-1 Antibody (aa1570-1600) - LS-C160967 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ZO1 Antibody IHC of formalin-fixed and paraffin-embedded lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TJP1 / ZO-1 Antibody (C-Terminus) IHC-plus™ - LS-B9774 from LifeSpan Bioscience

Prices $395.00
Sizes 300 µg
Host Goat
Clonality Polyclonal
Anti-TJP1 / ZO-1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9774 concentration 10 ug/ml.

Anti-TJP1 / ZO-1 Antibody - LS-C331048 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded H-kidney using NO1 antibody.

Anti-TJP1 / ZO-1 Antibody (aa1-296) IHC-plus™ - LS-B11010 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TJP1 / ZO-1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11010 concentration 10 ug/ml.

Anti-TJP1 / ZO-1 Antibody (aa463-1109) IHC-plus™ - LS-B2129 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ZO-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2129 concentration 5 ug/ml.

Anti-TJP1 / ZO-1 Antibody (aa935-984) IHC-plus™ - LS-B5625 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ZO-1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5625 concentration 5 ug/ml.

Anti-TJP1 / ZO-1 Antibody (aa1178-1527) - LS-C344084 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TJP1 antibody IHC-paraffin: Human Intestinal Cancer Tissue.

Tight Junction Protein 1 Antibody - NBP1-85046 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Tight Junction Protein 1 Antibody [NBP1-85046] - Analysis of Tight Junction Protein 1 in RIPA whole cell lysates of mouse primary choroid plexus epithelial cells using anti-Tight Junction Protein 1 antibody. Image from verified customer review.
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