| Gene Symbol |
TJP1
|
| Entrez Gene |
7082
|
| Alt Symbol |
ZO-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tight junction protein 1
|
| Other Description |
tight junction protein ZO-1|zona occludens 1|zonula occludens 1 protein
|
| Swissprots |
B4E3K1 Q2NKP3 Q07157 Q4ZGJ6
|
| Accessions |
AAG43399 AAY22179 EAW51506 EAW51507 EAW51508 EAW51509 EAW51510 Q07157 AB370197 BAF95000 AF035298 AK302971 BAG64116 AK304758 BAG65513 AK308113 BC036090 BC111712 AAI11713 BX640879 CAE45936 CN372462 CR749235 CAH18091 DA752892 EU831947 ACE87388 EU832042 ACE86704 XM_005254617 XP_005254674 XM_005254618 XP_005254675 XM_005254619 XP_005254676 XM_005254620 XP_005254677 XM_005254621 XP_005254678 XM_006720660 XP_006720723 XM_006725554 XP_006725617 XM_006725555 XP_006725618 XM_006725556 XP_006725619 XM_006725557 XP_006725620 XM_006725558 XP_006725621 XM_006725560 XP_006725623 XM_011521972 XP_011520274 XM_011521973 XP_011520275 XM_011521974 XP_011520276 XM_011521975 XP_011520277 XM_011547422 XP_011545724 XM_011547423 XP_011545725 XM_011547424 XP_011545726 XM_011548946 XP_011547248 XM_011548947 XP_011547249 XM_011548948 XP_011547250 XM_011548949 XP_011547251 XM_011548950 XP_011547252 XM_011548951 XP_011547253 XM_011548952 XP_011547254 XM_011548953 XP_011547255 XM_011548954 XP_011547256 NM_001301025 NP_001287954 NM_001301026 NP_001287955 NM_003257 NP_003248 NM_175610 NP_783297
|
| Function |
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. {ECO:0000269|PubMed:21240187}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.
|
| Tissue Specificity |
The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
|
| Top Pathways |
Adherens junction, Tight junction, Gap junction, Epithelial cell signaling in Helicobacter pylori infection, Vibrio cholerae infection
|