Gene Symbol | FANCC |
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Entrez Gene | 2176 |
Alt Symbol | FA3, FAC, FACC |
Species | Human |
Gene Type | protein-coding |
Description | Fanconi anemia, complementation group C |
Other Description | Fanconi anemia group C protein |
Swissprots | Q00597 B1ALR8 |
Accessions | AAA53104 AAO26042 EAW92626 EAW92627 EAW92628 EAW92629 Q00597 AI280997 AK222871 AK304887 BAG65624 AK310599 AK312548 AU132608 BC006303 BC015748 AAH15748 BC041030 CB052780 DB445119 DQ895422 ABM86348 EU176333 ABW03784 S64600 X66893 CAA47347 X66894 CAA47348 XM_005251802 XP_005251859 XM_006717001 XP_006717064 XM_006717002 XP_006717065 XM_006717004 XP_006717067 XM_011518365 XP_011516667 XM_011518366 XP_011516668 XM_011518367 XP_011516669 NM_000136 NP_000127 NM_001243743 NP_001230672 NM_001243744 NP_001230673 |
Function | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. {ECO:0000269|PubMed:11520787}. |
Subcellular Location | Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Fanconi anemia pathway |
FANCC CRISPR/Cas9 KO Plasmid (h) - sc-416477 from Santa Cruz Biotechnology
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FANCC HDR Plasmid (h) - sc-416477-HDR from Santa Cruz Biotechnology
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FANCC Double Nickase Plasmid (h) - sc-416477-NIC from Santa Cruz Biotechnology
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FANCC Double Nickase Plasmid (h2) - sc-416477-NIC-2 from Santa Cruz Biotechnology
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FANCC CRISPR Activation Plasmid (h) - sc-416477-ACT from Santa Cruz Biotechnology
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FANCC CRISPR Activation Plasmid (h2) - sc-416477-ACT-2 from Santa Cruz Biotechnology
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FANCC Lentiviral Activation Particles (h) - sc-416477-LAC from Santa Cruz Biotechnology
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FANCC Lentiviral Activation Particles (h2) - sc-416477-LAC-2 from Santa Cruz Biotechnology
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FANCC siRNA (h) - sc-35354 from Santa Cruz Biotechnology
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FANCC shRNA Plasmid (h) - sc-35354-SH from Santa Cruz Biotechnology
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FANCC shRNA (h) Lentiviral Particles - sc-35354-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU024341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1381 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11640 from Sigma-Aldrich
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FANCC siRNA (Human) - CRH1515 from Cohesion Biosciences
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FANCC RNAi - H00002176-R01 from Novus Biologicals
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FANCC - MBS8200338 from MyBioSource
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shRNA set against Human FANCC(NM_000136.2) - SHH048827 from Creative biogene
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Human FANCC siRNA - orb262017 from Biorbyt
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FANCC shRNA Plasmid (Human) - CHH1515 from Cohesion Biosciences
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FANCC miRNA 3'UTR clone - MiUTR1H-03505 from Creative biogene
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