Gene Symbol | HIST1H2BB |
---|---|
Entrez Gene | 3018 |
Alt Symbol | H2B.1, H2B/f, H2BFF |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 1, H2bb |
Other Description | H2B histone family, member F|histone 1, H2bb|histone H2B type 1-B|histone H2B.1|histone H2B.f |
Swissprots | P33778 Q4KN36 |
Accessions | AAN06685 CAA40406 EAW55513 P33778 BC096728 AAH96728 EU446966 ABZ92495 NM_021062 NP_066406 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |