| Gene Symbol |
HIST1H2BB
|
| Entrez Gene |
3018
|
| Alt Symbol |
H2B.1, H2B/f, H2BFF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2bb
|
| Other Description |
H2B histone family, member F|histone 1, H2bb|histone H2B type 1-B|histone H2B.1|histone H2B.f
|
| Swissprots |
P33778 Q4KN36
|
| Accessions |
AAN06685 CAA40406 EAW55513 P33778 BC096728 AAH96728 EU446966 ABZ92495 NM_021062 NP_066406
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|
