| Gene Symbol |
Casp3
|
| Entrez Gene |
12367
|
| Alt Symbol |
A830040C14Rik, AC-3, Apopain, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
caspase 3
|
| Other Description |
SREBP cleavage activity 1|caspase 3, apoptosis related cysteine protease|caspase-3|cysteine protease CPP32|protein Yama
|
| Swissprots |
O08668 Q8CHV5 Q9QWI4 P70677
|
| Accessions |
AAC52768 EDL35577 EDL35578 EDL35579 EDL35580 EDL35581 EDL35582 P70677 AK014231 AK049043 AK080651 BAC37969 AK146226 BC021500 BC038825 AAH38825 D86352 BAA21727 U19522 AAC53196 U49929 AAC52764 U63720 AAD09504 Y13086 CAA73528 NM_001284409 NP_001271338 NM_009810 NP_033940
|
| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis.
|
| Top Pathways |
Toxoplasmosis, TNF signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer
|