Ulk1

Gene Symbol Ulk1
Entrez Gene 22241
Alt Symbol AU041434, Unc51.1, mKIAA0722
Species Mouse
Gene Type protein-coding
Description unc-51 like kinase 1
Other Description serine/threonine-protein kinase ULK1|serine/threonine-protein kinase Unc51.1|unc-51-like kinase 1
Swissprots O70405 Q6PGB2
Accessions EDL20001 EDL20002 O70405 AF053756 AAC40118 AF072370 AAF23317 AK029439 AK122357 BAC65639 AK148317 BAE28476 AK154939 BAE32939 AK156534 BAE33746 AK201892 BC023281 BC030850 AAH30850 BC053062 BC057121 AAH57121 BC059835 AAH59835 XM_006534851 XP_006534914 XM_006534852 XP_006534915 XM_011249419 XP_011247721 XM_011249420 XP_011247722 NM_009469 NP_033495
Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269|PubMed:10624947, ECO:0000269|PubMed:19258318, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:21258367, ECO:0000269|PubMed:21460634}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:19258318}. Preautophagosomal structure {ECO:0000269|PubMed:19258318}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Top Pathways AMPK signaling pathway, Regulation of autophagy, mTOR signaling pathway

Recombinant Mouse Serine/threonine-protein kinase ULK1(Ulk1) ,partial - CSB-YP025612MO CSB-EP025612MO CSB-BP025612MO CSB-MP025612MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse ULK1 Protein - ULK1-17831M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Serine/threonine-protein kinase ULK1 (Ulk1), partial, Recombinant Protein - MBS1234365 from MyBioSource

Category Protein
Prices $1,015.00, $1,015.00, $1,245.00, $1,245.00, $1,535.00, $1,535.00, $1,995.00, $1,995.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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