| Gene Symbol |
Ulk1
|
| Entrez Gene |
22241
|
| Alt Symbol |
AU041434, Unc51.1, mKIAA0722
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
unc-51 like kinase 1
|
| Other Description |
serine/threonine-protein kinase ULK1|serine/threonine-protein kinase Unc51.1|unc-51-like kinase 1
|
| Swissprots |
O70405 Q6PGB2
|
| Accessions |
EDL20001 EDL20002 O70405 AF053756 AAC40118 AF072370 AAF23317 AK029439 AK122357 BAC65639 AK148317 BAE28476 AK154939 BAE32939 AK156534 BAE33746 AK201892 BC023281 BC030850 AAH30850 BC053062 BC057121 AAH57121 BC059835 AAH59835 XM_006534851 XP_006534914 XM_006534852 XP_006534915 XM_011249419 XP_011247721 XM_011249420 XP_011247722 NM_009469 NP_033495
|
| Function |
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269|PubMed:10624947, ECO:0000269|PubMed:19258318, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:21258367, ECO:0000269|PubMed:21460634}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:19258318}. Preautophagosomal structure {ECO:0000269|PubMed:19258318}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
|
| Top Pathways |
AMPK signaling pathway, Regulation of autophagy, mTOR signaling pathway
|