PIWIL3

Gene Symbol PIWIL3
Entrez Gene 440822
Alt Symbol HIWI3
Species Human
Gene Type protein-coding
Description piwi-like RNA-mediated gene silencing 3
Other Description piwi-like 3|piwi-like protein 3
Swissprots Q7Z3Z3
Accessions EAW59679 Q7Z3Z3 AB079368 BAC81343 AK302409 BAG63719 AK315806 BC144693 BC144696 BC167797 AAI67797 NM_001008496 NP_001008496 NM_001255975 NP_001242904 NR_045648 NR_045649
Function May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
Tissue Specificity Expressed in testis. {ECO:0000269|PubMed:12906857}.
Top Pathways Dorso-ventral axis formation

PIWIL3 CRISPR/Cas9 KO Plasmid (h) - sc-408003 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 HDR Plasmid (h) - sc-408003-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 Double Nickase Plasmid (h) - sc-408003-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 Double Nickase Plasmid (h2) - sc-408003-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 CRISPR Activation Plasmid (h) - sc-408003-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 CRISPR Activation Plasmid (h2) - sc-408003-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 Lentiviral Activation Particles (h) - sc-408003-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 Lentiviral Activation Particles (h2) - sc-408003-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL3 siRNA (h) - sc-76153 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIWIL3 shRNA Plasmid (h) - sc-76153-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIWIL3 shRNA (h) Lentiviral Particles - sc-76153-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN16849 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16849 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04222 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04222

PIWIL3 siRNA (Human) - CRJ8268 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PIWIL3 (NM_001008496.3) - SHH376308 from Creative biogene

Category siRNA
Species Reactivities Human

PIWIL3 shRNA Plasmid (Human) - CHJ8268 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PIWIL3 miRNA 3'UTR clone - MiUTR4H-TG06721 from Creative biogene

Species Reactivities Human
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