| Gene Symbol |
PIWIL3
|
| Entrez Gene |
440822
|
| Alt Symbol |
HIWI3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
piwi-like RNA-mediated gene silencing 3
|
| Other Description |
piwi-like 3|piwi-like protein 3
|
| Swissprots |
Q7Z3Z3
|
| Accessions |
EAW59679 Q7Z3Z3 AB079368 BAC81343 AK302409 BAG63719 AK315806 BC144693 BC144696 BC167797 AAI67797 NM_001008496 NP_001008496 NM_001255975 NP_001242904 NR_045648 NR_045649
|
| Function |
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in testis. {ECO:0000269|PubMed:12906857}.
|
| Top Pathways |
Dorso-ventral axis formation
|