IGHM

Gene Symbol	IGHM
Entrez Gene	3507
Alt Symbol	AGM1, MU, VH
Species	Human
Gene Type	other
Description	immunoglobulin heavy constant mu
Other Description	constant region of heavy chain of IgM|immunoglobulin mu chain
Swissprots	P01871 P20769
Accessions	AAB59422 BAA87067 CAA33065 P01871 AK090464 BAC03445 AK092976 AK097859 BAC05186 AK097950 BAC05203 AK129622 BAC85199 AK129637 BAC85202 AK130539 BAC85373 AK130577 BAC85385 AY570731 AAS88328 BC001872 BC002963 BC006180 BC009851 BC011857 BC015760 BC016381 BC017356 BC019235 BC020240 BC041037 BC073758 BC073767 BC089412 BX161420 CAD61894 BX248278 CAD62606 BX640620 CAE45774 BX640724 CAE45841 J00258 AAA53509 X17115 CAA34971 X58529 X67292 CAA47708 X67301 CAA47714 Y14737 CAA75032
Function	IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. {ECO:0000269|PubMed:3137579}.
Subcellular Location	Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IgM full length protein - ab167776 from Abcam Category Protein Source Native

Human IgM Kappa full length protein - ab99015 from Abcam Category Protein Source Native Species Human

Human IgM Antibody Blocking Peptide - LS-E8990 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg Species Human

Recombinant Human IgM Protein - H00003507-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IGHM-Antibody-N-term-Blocking-Peptide - BP7470a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human IgM PURIFIED IMMUNOGLOBULIN Protein (OPSA10629) - OPSA10629 from Aviva Systems Biology Category Protein Prices $440.00 Sizes 2 mg Species Human

IGHM - H00003507-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IGHM - H00003507-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IGHM fusion protein - ag1459 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Immunoglobulin M (IgM) - RPA543Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Immunoglobulin M (IgM) - RPA543Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Immunoglobulin M (IgM) - RPA543Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Immunoglobulin M (IgM) - RPA543Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Immunoglobulin M (IgM) - RPA543Bo01 from Uscn Life Science Inc. Category Protein Source E.coli Species Bovine

Recombinant Immunoglobulin M (IgM) - RPA543Ga01 from Uscn Life Science Inc. Category Protein Source E.coli Species Chicken

IgM, Human Myeloma Plasma - HU-IGMM from Molecular Innovations Category Protein Prices $265.00, $445.00 Sizes 5 mg, 10 mg Species Human

IgM, Human Plasma - HU-IGM from Molecular Innovations Category Protein Prices $265.00 Sizes 5 mg Source Human plasma Species Human

Human Immunoglobulin M (IgM) - PI50022 from AssayPro Prices $150.00 Sizes 1 mg Source Human Myeloma Plasma Species Human

Native Immunoglobulin M (IgM) - NPA543Hu01 from Cloud-clone Category Protein Source Human Species Human

Recombinant Immunoglobulin M (IgM) - RPA543Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Ig mu chain C region(IGHM) - CSB-YP360788HU CSB-EP360788HU CSB-BP360788HU CSB-MP360788HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human IgM full length protein - ab205807 from Abcam Category Protein Source Native

IgM - OBT1524 from AbD Serotec Category Protein Prices $328.00 Sizes 2 mg Source Purified IgM prepared by delipidation, selective precipitation and tandem molecular sieve chromatography. Species Human

Human IgM | AbD18705_hIgM - HCA191S from AbD Serotec Category Protein Prices $193.00 Sizes 2 ml Species Human

IgM Isotypic Control Protein (OPMA04398) - OPMA04398 from Aviva Systems Biology Category Protein Prices $200.00 Sizes 200 µg Source Mouse. Source: Tissue Culture

Search more