IGHM

Gene Symbol IGHM
Entrez Gene 3507
Alt Symbol AGM1, MU, VH
Species Human
Gene Type other
Description immunoglobulin heavy constant mu
Other Description constant region of heavy chain of IgM|immunoglobulin mu chain
Swissprots P01871 P20769
Accessions AAB59422 BAA87067 CAA33065 P01871 AK090464 BAC03445 AK092976 AK097859 BAC05186 AK097950 BAC05203 AK129622 BAC85199 AK129637 BAC85202 AK130539 BAC85373 AK130577 BAC85385 AY570731 AAS88328 BC001872 BC002963 BC006180 BC009851 BC011857 BC015760 BC016381 BC017356 BC019235 BC020240 BC041037 BC073758 BC073767 BC089412 BX161420 CAD61894 BX248278 CAD62606 BX640620 CAE45774 BX640724 CAE45841 J00258 AAA53509 X17115 CAA34971 X58529 X67292 CAA47708 X67301 CAA47714 Y14737 CAA75032
Function IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. {ECO:0000269|PubMed:3137579}.
Subcellular Location Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.

IgM (A-7) - sc-373781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IgM (A-7): sc-373781. Western blot analysis of IgM expression in NAMALWA (A), Raji (B), U-698-M (C) and Ramos (D) whole cell lysates.

IgM (A-15) - sc-34667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IgM (A-15): sc-34667. Western blot analysis of IgM expression in U-698-M (A) and Ramos (B) whole cell lysates.

IgM (G-12) - sc-376317 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IgM (G-12): sc-376317. Western blot analysis of IgM expression in NAMALWA (A) and BJAB (B) whole cell lysates.

IgM (F-15) - sc-34669 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IgM (F-15): sc-34669. Western blot analysis of IgM expression in U-698-M (A) and Ramos (B) whole cell lysates.

IgM (N-16) - sc-34670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IgM (N-16): sc-34670. Western blot analysis of IgM expression in U-698-M (A) and Ramos (B) whole cell lysates.

IgM (R1/69) - sc-53347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IgM (R1/69): sc-53347. Western blot analysis of IgM expression in human throat tissue extract (A) and U-698-M (B) and NAMALWA (C) whole cell lysates.

IgM (2C12-3) - sc-69920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IgM (2C12-3): sc-69920. Western blot analysis of IgM expression in BJAB whole cell lysate.

IgM (M11) - sc-66121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IgM (M11): sc-66121. Western blot analysis of IgM expression in BJAB whole cell lysate.

IgM Fc region (2B9) - sc-52010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IgM Fab fragment (2B9): sc-52010. Western blot analysis of IgM Fab fragment expression in BJAB whole cell lysate.

IgM Fab fragment (5E673) - sc-71330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

IgM Fab fragment (MA2) - sc-52011 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

IgM heavy chain (1F4) - sc-52008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IgM heavy chain (1F4): sc-52008. Western blot analysis of IgM heavy chain expression in U-698-M (A), Ramos (B) and BJAB (C) whole cell lysates.

Anti-Human IgM antibody - ab26867 from Abcam

Host Chicken
Clonality Polyclonal
Anti-Human IgM antibody (ab26867) at 1/500 dilution + Human plasma proteinSecondaryHRP conjugated goat anti-IgY at 1/1000 dilution

Anti-Human IgM antibody - ab130103 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Human IgM antibody - ab17150 from Abcam

Prices $370.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-Human IgM antibody [1F4] - ab1945 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 1F4

Anti-Human IgM antibody [2A6] - ab1946 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 2A6

Anti-Human IgM antibody [2B9] - ab1947 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 2B9

Anti-Human IgM antibody [CH2] (PerCP/Cy5.5®) - ab201295 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CH2

Anti-Human IgM antibody [EPR5539] - ab134159 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5539
All lanes : Anti-Human IgM antibody [EPR5539] (ab134159) at 1/1000 dilutionLane 1 : Human plasma lysateLane 2 : Human tonsil lysateLane 3 : Human spleen lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilutionObserved band size : 75 kDa (why is the actual band size different from the predicted?)

Anti-Human IgM antibody [IM260] - ab200541 from Abcam

Prices $359.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone IM260
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling IgM with ab2000541 antibody at 1 µg/mL.

Anti-Human IgM antibody [MA2] - ab1948 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone MA2

Anti-Human IgM antibody [MH15-1] - ab34029 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone MH15-1

Anti-Human IgM antibody, prediluted - ab939 from Abcam

Prices $370.00
Sizes 6 ml
Host Rabbit
Clonality Polyclonal

Anti-Human IgM antibody [R1/69] - ab17104 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone R1/69
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