| Gene Symbol |
IGHM
|
| Entrez Gene |
3507
|
| Alt Symbol |
AGM1, MU, VH
|
| Species |
Human
|
| Gene Type |
other
|
| Description |
immunoglobulin heavy constant mu
|
| Other Description |
constant region of heavy chain of IgM|immunoglobulin mu chain
|
| Swissprots |
P01871 P20769
|
| Accessions |
AAB59422 BAA87067 CAA33065 P01871 AK090464 BAC03445 AK092976 AK097859 BAC05186 AK097950 BAC05203 AK129622 BAC85199 AK129637 BAC85202 AK130539 BAC85373 AK130577 BAC85385 AY570731 AAS88328 BC001872 BC002963 BC006180 BC009851 BC011857 BC015760 BC016381 BC017356 BC019235 BC020240 BC041037 BC073758 BC073767 BC089412 BX161420 CAD61894 BX248278 CAD62606 BX640620 CAE45774 BX640724 CAE45841 J00258 AAA53509 X17115 CAA34971 X58529 X67292 CAA47708 X67301 CAA47714 Y14737 CAA75032
|
| Function |
IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. {ECO:0000269|PubMed:3137579}.
|
| Subcellular Location |
Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.
|