Gene Symbol | RAMP3 |
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Entrez Gene | 10268 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | receptor (G protein-coupled) activity modifying protein 3 |
Other Description | CRLR activity-modifying protein 3|calcitonin receptor-like receptor activity modifying protein 3|calcitonin-receptor-like receptor activity-modifying protein 3|receptor (calcitonin) activity modifying protein 3|receptor activity modifying protein 3|receptor activity-modifying protein 3|receptor-activity-modifying protein 3 |
Swissprots | Q7Z2Y1 O60896 |
Accessions | BAN10197 BAN10198 EAL23743 EAW61048 EAW61049 EAW61050 O60896 AJ001016 CAA04474 AK128765 AK222469 BAD96189 AK311871 BAG34812 AY265459 AAP23300 BC022304 AAH22304 BC053852 AAH53852 BP347072 DQ891371 ABM82297 HQ448585 ADQ33063 XM_006715631 XP_006715694 NM_005856 NP_005847 |
Function | Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. |
Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}. |
Top Pathways | Vascular smooth muscle contraction |
Human RAMP3 protein fragment - ab140554 from Abcam
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RAMP3 Antibody Blocking Peptide - LS-E3848 from LifeSpan Bioscience
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Recombinant Human RAMP3 Protein - H00010268-P01 from Novus Biologicals
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Recombinant Human RAMP3 Protein - NBP2-23402 from Novus Biologicals
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RAMP3-Antibody-C-term-Blocking-Peptide - BP16029b from Abgent, a WuXi AppTec company
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Human RAMP3 protein - orb139568 from Biorbyt
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Human RAMP3 protein - orb169159 from Biorbyt
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RAMP3 protein (His tag) - 80R-2674 from Fitzgerald
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RAMP3 (24-118, His-tag) - AR50794PU-N from Acris Antibodies
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RAMP3 (24-118, His-tag) - AR50794PU-S from Acris Antibodies
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RAMP3 - H00010268-P01-10 from Acris Antibodies
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RAMP3 - H00010268-P01-25 from Acris Antibodies
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RAMP3, 24-118aa, Human, His tag, E.coli - 01-P1970 from ARP American Research Products
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RAMP3 fusion protein - Ag2438 from Proteintech Group
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RAMP3 Human - PRPS-1374 from NeoScientific
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Recombinant Human RAMP3, His-tagged - RAMP3-7526H from Creative Biomart
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Recombinant Human RAMP3, Fc tagged - RAMP3-8607H from Creative Biomart
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Recombinant Human RAMP3, GST-tagged - RAMP3-2172H from Creative Biomart
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Human RAMP3 Protein (Fc Tag) - 13744-H02H-100 from Sino Biological
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Recombinant Human Receptor activity-modifying protein 3(RAMP3) - CSB-YP019306HU CSB-EP019306HU CSB-BP019306HU CSB-MP019306HU from Cusabio
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RAMP3, 24-118aa, Human, His tag, E.coli - ATGP1970 from ATGen
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Recombinant Human RAMP3 Protein (Fc tag) - PKSH030567 from Elabscience
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RAMP3 Peptide, Human - M34GP12947H from Creative Peptides
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RAMP3 - PAT-81969-1 from Nordic BioSite
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RAMP3 - PAT-81969-2 from Nordic BioSite
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