| Gene Symbol | THEMIS |
|---|---|
| Entrez Gene | 387357 |
| Alt Symbol | C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | thymocyte selection associated |
| Other Description | GRB2-associated protein|protein THEMIS|signaling phosphoprotein specific for T cells|thymocyte expressed molecule involved in selection|thymocyte selection pathway associated|thymocyte-expressed molecule involved in selection |
| Swissprots | Q5T3C4 Q8N1K5 Q6MZT7 F5H1J9 A1L4F0 B3KY07 Q5T3C5 A8K7N1 B3KT31 B3KW32 |
| Accessions | CAY56007 CBX47634 EAW48091 EAW48092 Q8N1K5 AK094863 BAG52943 AK097903 BAC05194 AK124031 BAG53994 AK128377 BAG54669 AK292046 BAF84735 BC043608 BC130516 AAI30517 BC144034 BG461112 BX640890 CAE45941 BX956657 DA818250 HQ258481 ADR83235 XM_011535813 XP_011534115 XM_011535814 XP_011534116 XM_011535815 XP_011534117 XM_011535816 XP_011534118 XM_011535817 XP_011534119 XM_011546483 XP_011544785 XM_011546484 XP_011544786 XM_011546485 XP_011544787 XM_011546486 XP_011544788 XM_011546487 XP_011544789 NM_001010923 NP_001010923 NM_001164685 NP_001158157 NM_001164687 NP_001158159 |
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |