Gene Symbol | CCL19 |
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Entrez Gene | 6363 |
Alt Symbol | CKb11, ELC, MIP-3b, MIP3B, SCYA19 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 19 |
Other Description | C-C motif chemokine 19|CC chemokine ligand 19|CK beta-11|EBI1 ligand chemokine|EBI1-ligand chemokine|MIP-3-beta|beta chemokine exodus-3|beta-chemokine exodus-3|epstein-Barr virus-induced molecule 1 ligand chemokine|exodus-3|macrophage inflammatory protein 3 beta|macrophage inflammatory protein 3-beta|small inducible cytokine subfamily A (Cys-Cys), member 19|small-inducible cytokine A19 |
Swissprots | O00697 O00736 Q99731 |
Accessions | ABK41949 CAA11307 EAW58416 Q99731 AB000887 BAA20383 AK311945 BAG34886 AX772806 CAE06252 BC027968 AAH27968 CR456868 CAG33149 DQ895236 ABM86162 EU176240 ABW03691 U77180 AAC50944 U88321 AAC23905 NM_006274 NP_006265 |
Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
Active Macrophage Inflammatory Protein 3 beta full length protein - ab9832 from Abcam
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Active mouse Macrophage Inflammatory Protein 3 beta full length protein - ab168015 from Abcam
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Active mouse Macrophage Inflammatory Protein 3 beta full length protein - ab191713 from Abcam
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Human Macrophage Inflammatory Protein 3 beta full length protein - ab97899 from Abcam
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Human Macrophage Inflammatory Protein 3 beta full length protein - ab175155 from Abcam
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Human Macrophage Inflammatory Protein 3 beta full length protein - ab176065 from Abcam
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Mouse Macrophage Inflammatory Protein 3 beta full length protein - ab50169 from Abcam
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CCL19/MIP-3 beta Recombinant Protein - H00006363-P02 from Novus Biologicals
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CCL19/MIP-3 beta Recombinant Protein - H00006363-P01 from Novus Biologicals
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CCL19/MIP-3 beta Protein - NBP1-44466 from Novus Biologicals
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CCL19/MIP-3 beta Recombinant Protein - P4430 from Novus Biologicals
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Recombinant Human CCL19/MIP-3 beta Protein - NBP1-99403 from Novus Biologicals
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CCL19 protein - GTX29832 from GeneTex
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CCL19 Recombinant Protein (Active) - GTX48367-PRO from GeneTex
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CCL19 recombinant protein - GTX65247 from GeneTex
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Recombinant Human CCL19/MIP-3 beta - 361-MI-025 from R&D Systems
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Recombinant Human CCL19/MIP-3 beta, CF - 361-MI-025/CF from R&D Systems
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Recombinant Mouse CCL19/MIP-3 beta - 440-M3-025 from R&D Systems
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Recombinant Mouse CCL19/MIP-3 beta, CF - 440-M3-025/CF from R&D Systems
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CCL19 Protein (OPCB00011) - OPCB00011 from Aviva Systems Biology
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Biotinylated CCL19 Protein (OPCB00021) - OPCB00021 from Aviva Systems Biology
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Human MIP-3b Protein (OPMA04653) - OPMA04653 from Aviva Systems Biology
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MIP 3b Protein (OPPA00405) - OPPA00405 from Aviva Systems Biology
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CCL23 Protein (OPPA02327) - OPPA02327 from Aviva Systems Biology
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Recombinant MIP-3 beta / CCL19 (OPSD00071) - OPSD00071 from Aviva Systems Biology
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