| Gene Symbol | CCL19 |
|---|---|
| Entrez Gene | 6363 |
| Alt Symbol | CKb11, ELC, MIP-3b, MIP3B, SCYA19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 19 |
| Other Description | C-C motif chemokine 19|CC chemokine ligand 19|CK beta-11|EBI1 ligand chemokine|EBI1-ligand chemokine|MIP-3-beta|beta chemokine exodus-3|beta-chemokine exodus-3|epstein-Barr virus-induced molecule 1 ligand chemokine|exodus-3|macrophage inflammatory protein 3 beta|macrophage inflammatory protein 3-beta|small inducible cytokine subfamily A (Cys-Cys), member 19|small-inducible cytokine A19 |
| Swissprots | O00697 O00736 Q99731 |
| Accessions | ABK41949 CAA11307 EAW58416 Q99731 AB000887 BAA20383 AK311945 BAG34886 AX772806 CAE06252 BC027968 AAH27968 CR456868 CAG33149 DQ895236 ABM86162 EU176240 ABW03691 U77180 AAC50944 U88321 AAC23905 NM_006274 NP_006265 |
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
MIP-3β siRNA (h) - sc-60001 from Santa Cruz Biotechnology
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MIP-3β shRNA Plasmid (h) - sc-60001-SH from Santa Cruz Biotechnology
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MIP-3β shRNA (h) Lentiviral Particles - sc-60001-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU013961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5604 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5604 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02615 from Sigma-Aldrich
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CCL19 siRNA (Human) - CRH4296 from Cohesion Biosciences
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CCL19 - MBS8228579 from MyBioSource
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shRNA set against Human CCL19 (NM_006274.2) - SHH257537 from Creative biogene
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shRNA set against Human CCL19(NM_006274.2) - SHG150513 from Creative biogene
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Human CCL19 siRNA - orb264798 from Biorbyt
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CCL19 shRNA Plasmid (Human) - CHH4296 from Cohesion Biosciences
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CCL19 miRNA 3'UTR clone - MiUTR1H-01795 from Creative biogene
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