Gene Symbol | Tlr13 |
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Entrez Gene | 279572 |
Alt Symbol | AI666735, Gm713 |
Species | Mouse |
Gene Type | protein-coding |
Description | toll-like receptor 13 |
Other Description | - |
Swissprots | Q3TDS2 Q148Y7 Q6R5N8 |
Accessions | EDL14060 Q6R5N8 AK155696 AK170044 BAE41528 AY510706 AAS37674 BC117913 AAI17914 BC117914 AAI17915 NM_205820 NP_991389 |
Function | Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. {ECO:0000269|PubMed:21131352, ECO:0000269|PubMed:22821982, ECO:0000269|PubMed:22896636}. |
Subcellular Location | Endosome membrane {ECO:0000269|PubMed:22896636}; Single-pass type I membrane protein {ECO:0000269|PubMed:22896636}. |
TLR13 CRISPR/Cas9 KO Plasmid (m) - sc-435527 from Santa Cruz Biotechnology
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TLR13 HDR Plasmid (m) - sc-435527-HDR from Santa Cruz Biotechnology
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TLR13 Double Nickase Plasmid (m) - sc-435527-NIC from Santa Cruz Biotechnology
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TLR13 Double Nickase Plasmid (m2) - sc-435527-NIC-2 from Santa Cruz Biotechnology
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TLR13 CRISPR Activation Plasmid (m) - sc-435527-ACT from Santa Cruz Biotechnology
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TLR13 CRISPR Activation Plasmid (m2) - sc-435527-ACT-2 from Santa Cruz Biotechnology
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TLR13 Lentiviral Activation Particles (m) - sc-435527-LAC from Santa Cruz Biotechnology
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TLR13 Lentiviral Activation Particles (m2) - sc-435527-LAC-2 from Santa Cruz Biotechnology
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TLR13 siRNA (m) - sc-154298 from Santa Cruz Biotechnology
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TLR13 shRNA Plasmid (m) - sc-154298-SH from Santa Cruz Biotechnology
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TLR13 shRNA (m) Lentiviral Particles - sc-154298-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN42894 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42894 from Sigma-Aldrich
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TLR13 siRNA (Mouse) - CRN4219 from Cohesion Biosciences
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TLR13 - MBS828860 from MyBioSource
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shRNA set against Mouse Tlr13 (NM_205820.1) - SHH427956 from Creative biogene
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Mouse TLR13 siRNA - orb293694 from Biorbyt
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TLR13 shRNA Plasmid (Mouse) - CHN4219 from Cohesion Biosciences
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TLR13 miRNA 3'UTR clone - MiUTR1M-11791 from Creative biogene
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