| Function |
Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. {ECO:0000269|PubMed:21131352, ECO:0000269|PubMed:22821982, ECO:0000269|PubMed:22896636}.
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![Western Blot: Mouse TLR13 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line [NBP2-26290] - Analysis of TLR13 expression in the TLR13 reporter cell line using an HA antibody (20 ug total protein/lane). Legend. Cont: Control, NF-kB/SEAPorterTM HEK 293 cell line; TLR13: TLR13 reporter cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10754_Mouse-TLR13-NF-kB-SEAP---(SEAPorter(TM))-Stable-Reporter-Cell-Line-Western-Blot-NBP2-26290-img0009.jpg)