PPP1R12A

Gene Symbol	PPP1R12A
Entrez Gene	4659
Alt Symbol	M130, MBS, MYPT1
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, regulatory subunit 12A
Other Description	myosin binding subunit|myosin phosphatase, target subunit 1|myosin phosphatase-targeting subunit 1|protein phosphatase 1 regulatory subunit 12A|protein phosphatase 1, regulatory (inhibitor) subunit 12A|protein phosphatase myosin-binding subunit
Swissprots	Q86WU3 Q9BYH0 B4DZ09 Q2NKL4 O14974 Q8NFR6 F8VWB4 Q569H0
Accessions	BAB39107 EAW97351 EAW97352 EAW97353 EAW97354 EAW97355 EAW97356 O14974 AF086032 AF458589 AAM49717 AK057712 AK125671 AK302692 BAG63921 AK314193 BAG36872 AY380574 AAQ88438 BC000812 BC013941 AAH13941 BC040375 BC047898 AAH47898 BC062560 BC092481 AAH92481 BC111752 AAI11753 D87930 BAA22378 DC350703 XM_005268887 XP_005268944 XM_011538374 XP_011536676 XM_011538375 XP_011536677 XM_011538376 XP_011536678 XM_011538377 XP_011536679 XM_011538378 XP_011536680 XM_011538379 XP_011536681 XM_011538380 XP_011536682 XM_011538381 XP_011536683 XM_011538382 XP_011536684 XM_011538383 XP_011536685 XM_011538384 XP_011536686 XM_011538385 XP_011536687 XR_944554 NM_001143885 NP_001137357 NM_001143886 NP_001137358 NM_001244990 NP_001231919 NM_001244992 NP_001231921 NM_002480 NP_002471
Function	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12923170, ECO:0000269|PubMed:18477460}. Note=Along actomyosin filaments and stress fibers.
Tissue Specificity	Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269|PubMed:20634291}.
Top Pathways	Focal adhesion, Vascular smooth muscle contraction, Oxytocin signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPP1R12A 293 Cell Lysate - 400836 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Myosin Phosphatase Overexpression Lysate (Native) - NBL1-14674 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PPP1R12A Over-expression Lysate Product - GWB-A4CC11 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Myosin Phosphatase Overexpression Lysate (Native) - NBP2-11066 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human PPP1R12A Knockdown Stable Cell Line - CSC-DC012231 from Creative biogene Category Cell Line Species Human

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