YWHAZ

Gene Symbol	YWHAZ
Entrez Gene	7534
Alt Symbol	14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD
Species	Human
Gene Type	protein-coding
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Other Description	14-3-3 delta\|14-3-3 protein zeta/delta\|14-3-3 protein/cytosolic phospholipase A2\|14-3-3 zeta\|epididymis luminal protein 4\|epididymis secretory protein Li 3\|phospholipase A2\|protein kinase C inhibitor protein 1\|protein kinase C inhibitor protein-1\|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide\|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide\|tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
Swissprots	Q6IN74 Q5XJ08 P29213 Q86V33 Q6NUR9 B7Z465 A8K1N0 Q6GPI2 P29312 Q32P43 P63104 Q6P3U9
Accessions	ABO15003 EAW91823 EAW91824 EAW91825 EAW91826 EAW91827 EAW91828 EAW91829 P63104 AA830489 AK289945 BAF82634 AK294647 BAH11832 AK296902 BAH12451 AK307506 AK315867 BAF98758 BC003623 AAH03623 BC013265 BC051814 AAH51814 BC063824 AAH63824 BC068456 AAH68456 BC070389 BC072426 AAH72426 BC073141 AAH73141 BC083508 AAH83508 BC099904 AAH99904 BC101483 AAI01484 BC108281 AAI08282 BC111951 AAI11952 BM783874 BQ605329 CN276619 CN276627 CR996247 DB472116 DC298291 DQ185048 ABD14427 DQ891706 ABM82632 DQ894884 ABM85810 EU794582 ACJ13636 EU794583 ACJ13637 M86400 AAA36446 S79449 AAD14300 U28964 AAC52052 XM_005251061 XP_005251118 XM_005251062 XP_005251119 XM_005251063 XP_005251120 XM_011517289 XP_011515591 XM_011517290 XP_011515592 NM_001135699 NP_001129171 NM_001135700 NP_001129172 NM_001135701 NP_001129173 NM_001135702 NP_001129174 NM_003406 NP_003397 NM_145690 NP_663723
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269\|PubMed:14578935, ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15644438, ECO:0000269\|PubMed:16376338, ECO:0000269\|PubMed:9360956}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:17081065}. Melanosome {ECO:0000269\|PubMed:17081065}. Note=Located to stage I to stage IV melanosomes.
Top Pathways	Cell cycle, Pathogenic Escherichia coli infection, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway

14-3-3 ζ/δ (D7H5) Rabbit mAb - 7413 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D7H5

Western blot analysis of extracts from various cell lines using 14-3-3 ζ/δ (D7H5) Rabbit mAb.

14-3-3 ζ/δ Antibody - 9639 from Cell Signaling Technology

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells using 14-3-3 zeta/delta Antibody.

14-3-3 ζ (C-16) - sc-1019 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

14-3-3 ζ (C-16): sc-1019. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor (A) and immunofluorescence staining of methanol-fixed KNRK cells (B) showing cytoplasmic staining.

14-3-3 ζ (L-15) - sc-31964 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

14-3-3 ζ (L-15): sc-31964. Western blot analysis of 14-3-3 ζ expression in HeLa whole cell lysate.

14-3-3 ζ (V-16) - sc-31965 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

14-3-3 ζ (V-16): sc-31965. Western blot analysis of 14-3-3 ζ expression in non-transfected: sc-117752 (A) and human 14-3-3 ζ transfected: sc-111573 (B) 293T whole cell lysates.

p-14-3-3 ζ (Ser 58) - sc-101623 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

p-14-3-3 ζ (Ser 58): sc-101623. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

Anti-14-3-3 delta + zeta (phospho T232) antibody - ab195909 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-14-3-3 delta + zeta (phospho T232) antibody (ab195909) at 1/500 dilutionLane 1 : UV treated Jurkat whole cell lysate with antigen specific peptideLane 2 : UV treated Jurkat whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-14-3-3 zeta (phospho S58) antibody - ab51109 from Abcam

Prices	$380.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Ab51109 staining human 14-3-3 zeta in human breast carcinoma tissue in immunohistochemistry using paraffin embedded tissue.

Anti-14-3-3 zeta (phospho S58) antibody - ab131337 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-14-3-3 zeta (phospho S58) antibody (ab131337) at 1/500 dilutionLane 1 : 3T3 cell extracts Lane 2 : 3T3 cell extracts treated with TNF-alpha

Anti-14-3-3 zeta (phospho T232) antibody - ab59374 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry analysis of paraffin-embedded human brain tissue using ab59374 at a 1/50-1/100 dilution.Left image: untreated.Right image: treated with immunizing phosphopeptide.

Anti-14-3-3 zeta antibody - ab51129 from Abcam

Prices	$398.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

This image shows paraffin-embedded human breast carcinoma tissue stained with ab51129 at a dilution of 1/100. Right hand image: tissue treated with immunising peptide; left hand image: untreated tissue

Anti-14-3-3 zeta antibody - ab63635 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-14-3-3 zeta antibody (ab63635) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : K562 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-14-3-3 zeta antibody - ab125309 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-14-3-3 zeta antibody (ab125309) at 1/200 dilution + 3T3 cell lysate

Anti-14-3-3 zeta antibody - ab189196 from Abcam

Prices	$384.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin embedded formalin fixed human prostate tissue labeling 14-3-3 zeta using ab189196 at 10 µg/ml.

Anti-14-3-3 zeta antibody - ab135823 from Abcam

Prices	$384.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-14-3-3 zeta antibody (ab135823) at 1/100 dilutionLane 1 : MDA-MB-231 cell lysateLane 2 : A2058 cell lysateLane 3 : Mouse cerebellum tissue lysateLane 4 : Mouse brain tissue lysateLysates/proteins at 35 µg per lane.

Anti-14-3-3 zeta antibody - ab37560 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-14-3-3 zeta antibody (ab37560) at 1/100 dilution + Jurkat cell lysate

Anti-14-3-3 zeta antibody - ab69593 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-14-3-3 zeta antibody (ab69593) at 1/500 dilutionLane 1 : extract from HeLa cellsLane 2 : extract from Jurkat cellsLane 3 : extract from COLO cellsLane 4 : extract from Jurkat cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-14-3-3 zeta antibody, prediluted - ab32623 from Abcam

Prices	$376.00
Sizes	7 ml
Host	Rabbit
Clonality	Polyclonal

IHC staining of formalin-fixed, paraffin-embedded human breast carcinoma with prediluted ab32623.

Anti-YWHAZ / 14-3-3 Zeta Antibody - LS-C20248 from LifeSpan Bioscience

Prices	$495.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

Anti-YWHAZ / 14-3-3 Zeta Antibody - LS-C34763 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µg
Host	Rabbit
Clonality	Polyclonal

Anti-YWHAZ / 14-3-3 Zeta Antibody (N-Terminus) - LS-C42377 from LifeSpan Bioscience

Prices	$390.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-YWHAZ / 14-3-3 Zeta Antibody - LS-C90217 from LifeSpan Bioscience

Prices	$575.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-YWHAZ / 14-3-3 Zeta Antibody (phospho-Ser58) - LS-C92056 from LifeSpan Bioscience

Prices	$315.00
Sizes	40 µg
Host	Rabbit
Clonality	Polyclonal

Anti-YWHAZ / 14-3-3 Zeta Antibody (aa134-149) - LS-C50367 from LifeSpan Bioscience

Prices	$530.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Human breast ca. stained with Anti-14-3-3 zeta

Anti-YWHAZ / 14-3-3 Zeta Antibody - LS-C122565 from LifeSpan Bioscience

Prices	$355.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

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