Ptprc

Gene Symbol	Ptprc
Entrez Gene	19264
Alt Symbol	B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4, T200, loc
Species	Mouse
Gene Type	protein-coding
Description	protein tyrosine phosphatase, receptor type, C
Other Description	leukocyte common antigen|lymphocyte antigen 5|lymphocyte common antigen|receptor-type tyrosine-protein phosphatase C
Swissprots	P06800 E9QLT5 Q61812 Q61813 Q61814 Q61815 Q78EF1
Accessions	AAA39418 AAA39460 AAA39462 AAB46374 CAJ01231 EDL39541 EDL39542 P06800 AK054056 BAC35638 AK079399 AK088215 AK088875 AK154893 BAE32907 AK169451 AK171802 AK172193 BC028512 AAH28512 BC084684 AAH84684 BC131655 BC167212 AAI67212 BM239381 BX517622 CA575153 CA577897 CK392851 EF101553 ABK96802 L36091 M11934 AAA39461 M14342 AAA39458 M14343 M15174 AAA40161 M17320 AAA60449 M92933 AAA39459 XM_006529257 XP_006529320 XM_006529258 XP_006529321 XM_006529259 XP_006529322 XM_006529260 XP_006529323 XM_006529261 XP_006529324 XM_006529262 XP_006529325 NM_001111316 NP_001104786 NM_001268286 NP_001255215 NM_011210 NP_035340
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. {ECO:0000250, ECO:0000269|PubMed:10415030}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse CD45 protein fragment - ab102105 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source E. coli Species Mouse

Recombinant Mouse CD45, CF - 114-CD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln24-Lys564 with a C-terminal 6-His tag

Mouse CD45 protein - orb138450 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Mouse CD45 protein - orb138451 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Mouse

Mouse CD45 protein (GST Tag) - orb138449 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Mouse

Mouse PTPRC Protein - abx068772 from Abbexa Category Protein Source E.coli Species Mouse

Mouse PTPRC Protein - abx068773 from Abbexa Category Protein Source E.coli Species Mouse

Protein Tyrosine Phosphatase Receptor Type C - 20-7409 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Protein Tyrosine Phosphatase Receptor Type C - 20-7410 from ARP American Research Products Category Protein Prices $429.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Mouse Protein Tyrosine Phosphatase, Receptor Type, C, GST-tagged - Ptprc-1623M from Creative Biomart Category Protein Species Mouse

Recombinant Mouse Ptprc, His & GST tagged - Ptprc-8677M from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Mouse

Recombinant Mouse Ptprc, DDDDK tagged - PTPRC-480M from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Mouse

Recombinant Mouse Ptprc, Fc tagged - Ptprc-550M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Ptprc, His-tagged - Ptprc-684M from Creative Biomart Category Protein Source NSO cells Species Mouse

Mouse CD45 / PTPRC Protein (aa 453-1152, His & GST Tag) - 50713-M20B-20 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Mouse

Mouse CD45 / PTPRC Protein (Fc Tag) - 50713-M02H1-50 from Sino Biological Category Protein Source Human Cells Species Mouse

Mouse CD45 / PTPRC Protein (aa 453-1152) - 50713-MCCB-20 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Mouse

Recombinant Protein Tyrosine Phosphatase Receptor Type C (PTPRC) - RPB030Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Protein Tyrosine Phosphatase Receptor Type C (PTPRC) - RPB030Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Receptor-type tyrosine-protein phosphatase C(Ptprc) - CSB-YP019049MO CSB-EP019049MO CSB-BP019049MO CSB-MP019049MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse CD45 Protein, CF - 114-CD from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Gln24-Lys564 with a C-terminal 6-His tag Species Mouse

Recombinant Mouse CD45 / PTPRC Protein (aa 453-1152) - PKSM040296 from Elabscience Category Protein Source Baculovirus-Insect Cells Species Mouse

Recombinant Mouse CD45 / PTPRC Protein (aa 453-1152, His & GST tag) - PKSM040297 from Elabscience Category Protein Source Baculoviru Species Mouse

Recombinant Mouse CD45 / PTPRC Protein (Fc tag) - PKSM040526 from Elabscience Category Protein Source Human Cell Species Mouse

PTPRC Recombinant Protein (OPCD06516) - OPCD06516 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

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