Ptprc

Gene Symbol Ptprc
Entrez Gene 19264
Alt Symbol B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4, T200, loc
Species Mouse
Gene Type protein-coding
Description protein tyrosine phosphatase, receptor type, C
Other Description leukocyte common antigen|lymphocyte antigen 5|lymphocyte common antigen|receptor-type tyrosine-protein phosphatase C
Swissprots P06800 E9QLT5 Q61812 Q61813 Q61814 Q61815 Q78EF1
Accessions AAA39418 AAA39460 AAA39462 AAB46374 CAJ01231 EDL39541 EDL39542 P06800 AK054056 BAC35638 AK079399 AK088215 AK088875 AK154893 BAE32907 AK169451 AK171802 AK172193 BC028512 AAH28512 BC084684 AAH84684 BC131655 BC167212 AAI67212 BM239381 BX517622 CA575153 CA577897 CK392851 EF101553 ABK96802 L36091 M11934 AAA39461 M14342 AAA39458 M14343 M15174 AAA40161 M17320 AAA60449 M92933 AAA39459 XM_006529257 XP_006529320 XM_006529258 XP_006529321 XM_006529259 XP_006529322 XM_006529260 XP_006529323 XM_006529261 XP_006529324 XM_006529262 XP_006529325 NM_001111316 NP_001104786 NM_001268286 NP_001255215 NM_011210 NP_035340
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. {ECO:0000250, ECO:0000269|PubMed:10415030}.
Subcellular Location Membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis

CD45 (I3/2.3) - sc-52491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (I3/2.3): sc-52491. Western blot analysis of CD45 expression in BYDP (A) and TK-1 (B) whole cell lysates.

CD45 (MB4B4) - sc-21739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (MB4B4) PE: sc-21739 PE. FCM analysis of C57BL/6 mouse splenocytes. Black line histogram represents the isotype control: normal rat IgG<sub>2a</sub>, sc-2872.

CD45 (30-F11) - sc-53665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (30-F11): sc-53665. Indirect FCM analysis of mouse peripheral blood leukocytes stained with CD45 (30-F11), followed by PE-conjugated goat anti-rat IgG: sc-3740. Black line histogram represents the isotype control, normal rat IgG<sub>2b</sub>: sc-3884.

CD45 (3H1379) - sc-70700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (3H1379): sc-70700. Western blot analysis of CD45 expression in BYDP whole cell lysate.

CD45R (RA3-6B2) - sc-19597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45R (RA3-6B2) PE: sc-19597 PE. FCM analysis of mouse peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal rat IgG<sub>2a</sub>: sc-2872.

CD45R (RA3-3A1) - sc-19598 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45R (RA3-3A1) FITC: sc-19598 FITC. FCM analysis of Balb/c mouse splenocytes. Black line histogram represents the isotype control, normal rat IgG: sc-2340.

CD45RA (14.8) - sc-18865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45RA (14.8) PE: sc-18865 PE. FCM analysis of mouse peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal rat IgG<sub>2b</sub>: sc-2873.

CD45RC (IBL-8) - sc-59076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rat
Clonality Monoclonal
CD45RC (IBL-8): sc-59076. Western blot analysis of CD45RC expression in BYDP whole cell lysate (A) and mouse thymus tissue extract (B).

CD45RC (GL24) - sc-52495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rat
Clonality Monoclonal
CD45RC (GL24): sc-52495. Western blot analysis of CD45RC expression in mouse PBL (A) and BYDP (B) whole cell lysates and mouse thymus tissue extract (C).

CD45RC (C455.1F) - sc-52494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rat
Clonality Monoclonal
CD45RC (C455.1F): sc-52494. Western blot analysis of CD45RC expression in mouse PBL (A) and BYDP (B) whole cell lysates.

CD45RC (2Q1664) - sc-70709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rat
Clonality Monoclonal
CD45RC (2Q1664): sc-70709. Western blot analysis of CD45RC expression in mouse PBL (A) and BYDP (B) whole cell lysates and mouse thymus tissue extract (C).

Anti-CD45.1 antibody [A20] - ab25078 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (Allophycocyanin) - ab25348 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (Allophycocyanin/Cy7 ®) - ab46823 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (Biotin) - ab25011 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (Cy5 ®) - ab24982 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (FITC) - ab24917 from Abcam

Prices $190.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20
SJL spleeen cells were stained with ab24917, following which small lymphocytes were gated and analyzed on a FACScanTM flow cytometer (BIDS, San Jose, CA).

Anti-CD45.1 antibody [A20] (PE/Cy5®) - ab25349 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (PE/Cy5.5 ®) - ab25049 from Abcam

Prices $186.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (PE/Cy7 ®) - ab25462 from Abcam

Prices $186.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45.1 antibody [A20] (Phycoerythrin) - ab25012 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone A20

Anti-CD45 antibody [104] (Cy5 ®) - ab25350 from Abcam

Prices $189.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 104
ab25350 staining CD45 in Mouse spleen cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Target Retrieval Solution pH6.1 and blocked with Rodent Block M for 30 minutes at 25°C. Samples were incubated with primary antibody (1/50 in Antibody Dilutent) for 12 hours at 4°C.See Abreview

Anti-CD45 antibody [104] (FITC) - ab95785 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 104
Staining of BALB/c splenocytes with 0.25 µg of Mouse IgG2a ? Isotype Control FITC (open histogram) or 0.25 µg of ab95785 (filled histogram). Total viable cells were used for analysis.

Anti-CD45 antibody [104-2] - ab25052 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 104-2
Analysis of C57BL/6 mouse splenocyte necrosis after exposure to Trypanosoma evansi trypanosomes in the presence or absence of anti-CD45 antibodies. Splenocyte necrosis was blocked with ab25052 at 15 µg/5.105 cells. C: Mock-exposed splenocytes T: Splenocytes exposed to the trypanosomes after preconditioning with PBS T CD45.1: Splenocytes exposed to the trypanosomes after preconditioning with ab25078 T CD45.2: Splenocytes exposed to the trypanosomes after preconditioning with ab25052

Anti-CD45 antibody [104-2] (Allophycocyanin) - ab25326 from Abcam

Prices $186.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 104-2
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