| Gene Symbol | Ptprc |
|---|---|
| Entrez Gene | 19264 |
| Alt Symbol | B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4, T200, loc |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, C |
| Other Description | leukocyte common antigen|lymphocyte antigen 5|lymphocyte common antigen|receptor-type tyrosine-protein phosphatase C |
| Swissprots | P06800 E9QLT5 Q61812 Q61813 Q61814 Q61815 Q78EF1 |
| Accessions | AAA39418 AAA39460 AAA39462 AAB46374 CAJ01231 EDL39541 EDL39542 P06800 AK054056 BAC35638 AK079399 AK088215 AK088875 AK154893 BAE32907 AK169451 AK171802 AK172193 BC028512 AAH28512 BC084684 AAH84684 BC131655 BC167212 AAI67212 BM239381 BX517622 CA575153 CA577897 CK392851 EF101553 ABK96802 L36091 M11934 AAA39461 M14342 AAA39458 M14343 M15174 AAA40161 M17320 AAA60449 M92933 AAA39459 XM_006529257 XP_006529320 XM_006529258 XP_006529321 XM_006529259 XP_006529322 XM_006529260 XP_006529323 XM_006529261 XP_006529324 XM_006529262 XP_006529325 NM_001111316 NP_001104786 NM_001268286 NP_001255215 NM_011210 NP_035340 |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. {ECO:0000250, ECO:0000269|PubMed:10415030}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250}. |
| Top Pathways | T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis |