| Gene Symbol |
NFKBIE
|
| Entrez Gene |
4794
|
| Alt Symbol |
IKBE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
|
| Other Description |
I-kappa-B-epsilon|NF-kappa-B inhibitor epsilon|NF-kappa-BIE|ikB-E|ikB-epsilon|ikappaBepsilon
|
| Swissprots |
Q5T9V9 O00221
|
| Accessions |
AAM27002 AAV31776 EAX04262 EAX04263 EAX04264 O00221 AK130739 BAC85418 AK301360 BAH13464 BC011676 AAH11676 BC063609 AAH63609 BC166665 AAI66665 BG759212 BX367256 U91616 AAC51216 NM_004556 NP_004547
|
| Function |
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
|
| Top Pathways |
T cell receptor signaling pathway, B cell receptor signaling pathway, Adipocytokine signaling pathway, Neurotrophin signaling pathway, Epstein-Barr virus infection
|