NFKBIE

Gene Symbol	NFKBIE
Entrez Gene	4794
Alt Symbol	IKBE
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Other Description	I-kappa-B-epsilon\|NF-kappa-B inhibitor epsilon\|NF-kappa-BIE\|ikB-E\|ikB-epsilon\|ikappaBepsilon
Swissprots	Q5T9V9 O00221
Accessions	AAM27002 AAV31776 EAX04262 EAX04263 EAX04264 O00221 AK130739 BAC85418 AK301360 BAH13464 BC011676 AAH11676 BC063609 AAH63609 BC166665 AAI66665 BG759212 BX367256 U91616 AAC51216 NM_004556 NP_004547
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269\|PubMed:9315679}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Top Pathways	T cell receptor signaling pathway, B cell receptor signaling pathway, Adipocytokine signaling pathway, Neurotrophin signaling pathway, Epstein-Barr virus infection

Phospho-IκBε (Ser18/22) Antibody - 4924 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from 293 cells treated with TNF-α (20 ng/ml) for the indicated times, using Phospho-IκBε (Ser18/22) Antibody.

IκBε Antibody - 9249 from Cell Signaling Technology

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa cells, untreated, TNF-α-treated #2169 (20ng/ml), calyculin A-treated #9902 (50nM) or both, using IκBε Antibody.

IκB-ε (G-4) - sc-7275 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

IκB-ε (G-4): sc-7275. Western blot analysis of IκB-ε expression in THP-1 whole cell lysate.

IκB-ε (M-121) - sc-7156 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of IκB-ε expression in WEHI-231 whole cell lysates (A,B). Antibodies tested include IκB-ε (M-364): sc-7155 (A) and IκB-ε (M-121): sc-7156 (B).

IκB-ε (M-364) - sc-7155 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

IκB-&epsilon (21) - sc-135945 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

IκB-ε (21): sc-135945. Western blot analysis of IκB-ε expression in A-431 whole cell lysate.

p-IκB-ε (Ser 22) - sc-101705 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

p-IκB-ε (Ser 22): sc-101705. Western blot analysis of phosphorylated IκB-ε expression in untreated (A) and TNF-α-treated (B) 293 whole cell lysates.

Anti-IKB epsilon (phospho S22) antibody - ab75907 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab75907 at 1/50 dilution staining IKB epsilon in human breast carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-IKB epsilon (phospho S22) antibody - ab51146 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ab51146 at 1/50 dilution staining Human breast carcinoma tissue with and without blocking peptide; paraffin embedded.

Anti-IKB epsilon antibody - ab51147 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IKB epsilon antibody (ab51147) at 1/500 dilutionLane 1 : Lysate of Hela cells treated with TNF-aLane 2 : Lysate of Hela cells treated with TNF-a with immunizing peptideLysates/proteins at 30 µg per lane.

Anti-IKB epsilon antibody - ab119946 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-IKB epsilon antibody (ab119946) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : Raji cell lysate

Anti-IKB epsilon antibody [EPR901(2)] - ab134143 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR901(2)

All lanes : Anti-IKB epsilon antibody [EPR901(2)] (ab134143) at 1/1000 dilutionLane 1 : THP-1 cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : A375 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/2000 dilution

Anti-NFKBIE / IKB Epsilon Antibody (aa207-440) - LS-C294625 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant NFKBIE / IKB Epsilon.

Anti-NFKBIE / IKB Epsilon Antibody (aa131-180) - LS-C117525 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of HeLa cells, using IkappaB-epsilon (Ab-22) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-NFKBIE / IKB Epsilon Antibody (phospho-Ser22) - LS-C199101 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human breast carcinoma, using IkappaB-epsilon (Phospho-Ser22) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-NFKBIE / IKB Epsilon Antibody (Ser22) - LS-C34479 from LifeSpan Bioscience

Prices	$265.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using IkB-e(Ab-22) antibody (left) or the same antibody preincubated with blocking peptide (right).

Anti-NFKBIE / IKB Epsilon Antibody (phospho-Ser22) - LS-C34168 from LifeSpan Bioscience

Prices	$285.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using IkB-e(Phospho-Ser22) antibody (left) or the same antibody preincubated with blocking peptide (right).

Anti-NFKBIE / IKB Epsilon Antibody (Internal, clone EPR901(2)) - LS-C138321 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR901(2)

IHC of paraffin-embedded human tonsil tissue using anti-IkappaB epsilon antibody.

Anti-NFKBIE / IKB Epsilon Antibody (Asp17) - LS-C176084 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of IB- (D17) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-NFKBIE / IKB Epsilon Antibody (phospho-Ser22) - LS-C335872 from LifeSpan Bioscience

Prices	$285.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-NFKBIE-S22 antibody.

Anti-NFKBIE / IKB Epsilon Antibody (phospho-Ser22) - LS-C123821 from LifeSpan Bioscience

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NFKBIE / IKB Epsilon Antibody - LS-C123822 from LifeSpan Bioscience

Prices	$355.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NFKBIE / IKB Epsilon Antibody (aa317-500) - LS-C178746 from LifeSpan Bioscience

Prices	$255.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NFKBIE / IKB Epsilon Antibody (aa207-440, FITC) - LS-C301476 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NFKBIE / IKB Epsilon Antibody (aa207-440, Biotin) - LS-C302737 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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