JUP

Gene Symbol	JUP
Entrez Gene	3728
Alt Symbol	ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Species	Human
Gene Type	protein-coding
Description	junction plakoglobin
Other Description	catenin (cadherin-associated protein), gamma 80kDa|desmoplakin III|desmoplakin-3
Swissprots	Q9BWC4 Q9HCX9 Q7L3S5 Q15151 P14923 Q86W21 Q15093
Accessions	AAG16727 BAA09435 CAC04246 CAP07504 CAP11472 CAR97086 CAT82323 CCQ43676 EAW60762 EAW60763 EAW60764 EAW60765 P14923 AK226051 AY243535 AAO85780 BC000441 AAH00441 BC011865 AAH11865 DQ891420 ABM82346 DQ894594 ABM85520 M23410 AAA64895 Z68228 CAA92522 XM_006721873 XP_006721936 XM_006721874 XP_006721937 XM_006721875 XP_006721938 XM_006721878 XP_006721941 XM_011524753 XP_011523055 XM_011524754 XP_011523056 XM_011524755 XP_011523057 XM_011524756 XP_011523058 XM_011524757 XP_011523059 XM_011524758 XP_011523060 NM_002230 NP_002221 NM_021991 NP_068831
Function	Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Location	Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form.
Top Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® γ-Catenin siRNA I - 6226 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® γ-Catenin siRNA II - 6239 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

γ-catenin CRISPR/Cas9 KO Plasmid (h) - sc-401640 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin HDR Plasmid (h) - sc-401640-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin Double Nickase Plasmid (h) - sc-401640-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin Double Nickase Plasmid (h2) - sc-401640-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin CRISPR Activation Plasmid (h) - sc-401640-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin CRISPR Activation Plasmid (h2) - sc-401640-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin Lentiviral Activation Particles (h) - sc-401640-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin Lentiviral Activation Particles (h2) - sc-401640-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

γ-catenin siRNA (h) - sc-29324 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

γ-catenin shRNA Plasmid (h) - sc-29324-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

γ-catenin shRNA (h) Lentiviral Particles - sc-29324-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

gamma Catenin RNAi - H00003728-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10887 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10887 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08101 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08101

JUP siRNA (Human) - CRH2509 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

gamma Catenin RNAi - H00003728-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

JUP, siRNA - MBS8238804 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human JUP (NM_002230.2) - SHH322311 from Creative biogene Category siRNA Species Reactivities Human

Human JUP siRNA - orb263011 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JUP shRNA Plasmid (Human) - CHH2509 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

JUP miRNA 3'UTR clone - MiUTR3H-01765 from Creative biogene Species Reactivities Human

JUP miRNA 3'UTR clone - MiUTR3H-01766 from Creative biogene Species Reactivities Human

Search more