JUP

Gene Symbol	JUP
Entrez Gene	3728
Alt Symbol	ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Species	Human
Gene Type	protein-coding
Description	junction plakoglobin
Other Description	catenin (cadherin-associated protein), gamma 80kDa|desmoplakin III|desmoplakin-3
Swissprots	Q9BWC4 Q9HCX9 Q7L3S5 Q15151 P14923 Q86W21 Q15093
Accessions	AAG16727 BAA09435 CAC04246 CAP07504 CAP11472 CAR97086 CAT82323 CCQ43676 EAW60762 EAW60763 EAW60764 EAW60765 P14923 AK226051 AY243535 AAO85780 BC000441 AAH00441 BC011865 AAH11865 DQ891420 ABM82346 DQ894594 ABM85520 M23410 AAA64895 Z68228 CAA92522 XM_006721873 XP_006721936 XM_006721874 XP_006721937 XM_006721875 XP_006721938 XM_006721878 XP_006721941 XM_011524753 XP_011523055 XM_011524754 XP_011523056 XM_011524755 XP_011523057 XM_011524756 XP_011523058 XM_011524757 XP_011523059 XM_011524758 XP_011523060 NM_002230 NP_002221 NM_021991 NP_068831
Function	Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Location	Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Membrane {ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Note=Cytoplasmic in a soluble and membrane-associated form.
Top Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JUP overexpression lysate - LY400807 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

JUP overexpression lysate - LY411834 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

JUP overexpression lysate - LY429669 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

JUP 293 Cell Lysate - 400773 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

gamma Catenin Overexpression Lysate (Native) - NBL1-12118 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

γ-catenin (h): 293T Lysate - sc-159343 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

JUP Over-expression Lysate Product - GWB-C2DBE7 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

gamma Catenin Overexpression Lysate (Native) - NBP2-11586 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

gamma Catenin Overexpression Lysate (Native) - NBP2-11266 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

gamma Catenin Overexpression Lysate (Denatured) - H00003728-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human JUP Knockdown Stable Cell Line - CSC-DC007881 from Creative biogene Category Cell Line Species Human

Human JUP Knockout Cell Line-HEK293T - CSC-RT0962 from Creative biogene Category Cell Line Species Human

JUP KO Cell Lysate-HEK293T - CLKO-0453 from Creative biogene Category Cell Lysate

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