| Gene Symbol | CNTN1 |
|---|---|
| Entrez Gene | 1272 |
| Alt Symbol | F3, GP135, MYPCN |
| Species | Human |
| Gene Type | protein-coding |
| Description | contactin 1 |
| Other Description | contactin-1|glycoprotein gP135|neural cell surface protein F3 |
| Swissprots | Q7M4P0 A8K0Y3 Q8N466 Q14030 Q12860 Q12861 A8K0H9 |
| Accessions | EAW57822 EAW57823 EAW57824 Q12860 AI473107 AK289544 BAF82233 AK289698 BAF82387 BC036569 AAH36569 BM717031 BX648591 BY799936 DA215712 DQ442053 DQ442054 U07819 AAA67920 U07820 AAA67921 Z21488 CAA79696 XM_005268651 XP_005268708 XM_006719241 XP_006719304 XM_011537926 XP_011536228 XM_011537927 XP_011536229 NM_001256063 NP_001242992 NM_001256064 NP_001242993 NM_001843 NP_001834 NM_175038 NP_778203 |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. |
| Tissue Specificity | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. {ECO:0000269|PubMed:2026173, ECO:0000269|PubMed:8164510}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
Contactin 1 CRISPR/Cas9 KO Plasmid (h) - sc-403437 from Santa Cruz Biotechnology
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Contactin 1 HDR Plasmid (h) - sc-403437-HDR from Santa Cruz Biotechnology
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Contactin 1 Double Nickase Plasmid (h) - sc-403437-NIC from Santa Cruz Biotechnology
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Contactin 1 Double Nickase Plasmid (h2) - sc-403437-NIC-2 from Santa Cruz Biotechnology
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Contactin 1 CRISPR Activation Plasmid (h) - sc-403437-ACT from Santa Cruz Biotechnology
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Contactin 1 CRISPR Activation Plasmid (h2) - sc-403437-ACT-2 from Santa Cruz Biotechnology
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Contactin 1 Lentiviral Activation Particles (h) - sc-403437-LAC from Santa Cruz Biotechnology
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Contactin 1 Lentiviral Activation Particles (h2) - sc-403437-LAC-2 from Santa Cruz Biotechnology
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Contactin 1 siRNA (h) - sc-43695 from Santa Cruz Biotechnology
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Contactin 1 shRNA Plasmid (h) - sc-43695-SH from Santa Cruz Biotechnology
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Contactin 1 shRNA (h) Lentiviral Particles - sc-43695-V from Santa Cruz Biotechnology
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Coagulation Factor III/Tissue Factor RNAi - H00002152-R02 from Novus Biologicals
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MISSION® esiRNA - EHU073341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6340 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6340 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01595 from Sigma-Aldrich
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CNTN1 siRNA (Human) - CRH0892 from Cohesion Biosciences
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CNTN1 - MBS8237977 from MyBioSource
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Contactin 1 CRISPR/Cas9 KO Plasmid (h2) - sc-403437-KO-2 from Santa Cruz Biotechnology
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Contactin 1 HDR Plasmid (h2) - sc-403437-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CNTN1 (NM_001843.3) - SHH266669 from Creative biogene
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Human CNTN1 siRNA - orb261394 from Biorbyt
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CNTN1 shRNA Plasmid (Human) - CHH0892 from Cohesion Biosciences
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CNTN1 miRNA 3'UTR clone - MiUTR3H-03074 from Creative biogene
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CNTN1 miRNA 3'UTR clone - MiUTR3H-03075 from Creative biogene
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