Gene Symbol | PPP1R12C |
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Entrez Gene | 54776 |
Alt Symbol | LENG3, MBS85, p84, p85 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 1, regulatory subunit 12C |
Other Description | leukocyte receptor cluster (LRC) encoded novel gene 3|leukocyte receptor cluster (LRC) member 3|myosin-binding subunit 85|protein phosphatase 1 myosin-binding subunit of 85 kDa|protein phosphatase 1 myosin-binding subunit p85|protein phosphatase 1 regulatory subunit 12C|protein phosphatase 1, regulatory (inhibitor) subunit 12C |
Swissprots | Q96HW1 Q7L8F7 Q9H5H5 B4DME2 Q9NT00 Q6ZPD1 Q59FK8 Q9BZL4 |
Accessions | EAW72332 EAW72333 EAW72334 EAW72335 Q9BZL4 AA551617 AB209452 BAD92689 AF211968 AF312028 AAG60045 AK027086 BAB15651 AK129529 BAC85179 AK297187 BAG59676 AK297426 BAG59854 AL137618 CAB70844 BC008030 AAH08030 BC010628 BC156295 AAI56296 HY013088 XM_005259013 XP_005259070 XM_011527045 XP_011525347 XR_935836 NM_001271618 NP_001258547 NM_017607 NP_060077 |
Function | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:12923170}. Note=Along actomyosin filaments and stress fibers. {ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:12923170}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in heart. {ECO:0000269|PubMed:11399775}. |
Top Pathways | Focal adhesion, Vascular smooth muscle contraction, Oxytocin signaling pathway, Proteoglycans in cancer, Regulation of actin cytoskeleton |
PPP1R12C CRISPR/Cas9 KO Plasmid (h) - sc-412332 from Santa Cruz Biotechnology
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PPP1R12C HDR Plasmid (h) - sc-412332-HDR from Santa Cruz Biotechnology
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PPP1R12C Double Nickase Plasmid (h) - sc-412332-NIC from Santa Cruz Biotechnology
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PPP1R12C Double Nickase Plasmid (h2) - sc-412332-NIC-2 from Santa Cruz Biotechnology
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PPP1R12C CRISPR Activation Plasmid (h) - sc-412332-ACT from Santa Cruz Biotechnology
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PPP1R12C CRISPR Activation Plasmid (h2) - sc-412332-ACT-2 from Santa Cruz Biotechnology
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PPP1R12C Lentiviral Activation Particles (h) - sc-412332-LAC from Santa Cruz Biotechnology
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PPP1R12C Lentiviral Activation Particles (h2) - sc-412332-LAC-2 from Santa Cruz Biotechnology
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PPP1R12C siRNA (h) - sc-106437 from Santa Cruz Biotechnology
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PPP1R12C shRNA Plasmid (h) - sc-106437-SH from Santa Cruz Biotechnology
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PPP1R12C shRNA (h) Lentiviral Particles - sc-106437-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU102801 from Sigma-Aldrich
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MISSION® esiRNA - EHU042981 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0533 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0532 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17261 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04478 from Sigma-Aldrich
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PPP1R12C siRNA (Human) - CRJ0210 from Cohesion Biosciences
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shRNA set against Human PPP1R12C (NM_017607.3) - SHH381032 from Creative biogene
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Human PPP1R12C siRNA - orb270711 from Biorbyt
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PPP1R12C shRNA Plasmid (Human) - CHJ0210 from Cohesion Biosciences
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PPP1R12C miRNA 3'UTR clone - MiUTR3H-12803 from Creative biogene
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