UBE2B

Gene Symbol	UBE2B
Entrez Gene	7320
Alt Symbol	E2-17kDa, HHR6B, HR6B, RAD6B, UBC2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2B
Other Description	E2 protein|RAD6 homolog B|ubiquitin carrier protein B|ubiquitin-conjugating enzyme E2 B|ubiquitin-conjugating enzyme E2-17 kDa|ubiquitin-conjugating enzyme E2B (RAD6 homolog)|ubiquitin-protein ligase B
Swissprots	D3DQA2 Q9D0J6 Q4PJ15 P23567 P63146 B2R503
Accessions	AAY68224 EAW62257 EAW62258 P63146 AK312012 BAG34950 BC001694 BC005979 AAH05979 BC008404 AAH08404 BC008470 AAH08470 BT007071 AAP35734 BU954901 CR407634 CAG28562 DA523817 DQ893113 ABM84039 DQ896387 ABM87386 M74525 AAA35982 T88933 X53251 CAA37339 NM_003337 NP_003328
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:1717990, ECO:0000269|PubMed:20061386}.
Subcellular Location	Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Ube2B full length protein - ab188714 from Abcam Category Protein Prices $276.00 Sizes 50 µg Source E. coli Species Human

Hepatitis C Virus Hepatitis C Virus NS4A full length protein - ab84350 from Abcam Category Protein Prices $270.00 Sizes 10 µg Source E. coli Species Hepatitis virus

Human Hepatitis C Virus E2 protein fragment - ab180302 from Abcam Category Protein Source E. coli Species Human

Human Ube2B full length protein - ab151807 from Abcam Category Protein Source E. coli Species Human

Human Ube2B full length protein - ab95484 from Abcam Category Protein Source E. coli Species Human

Human Ube2B full length protein - ab73536 from Abcam Category Protein Source E. coli Species Human

HR6B / UBE2B Antibody Blocking Peptide - LS-E6862 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HR6B/UBE2B Protein - NBP2-35088 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

HR6B/UBE2B Recombinant Protein - H00007320-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HR6B/UBE2B Partial Recombinant Protein - H00007320-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HR6B/UBE2B Protein - NBP1-44455 from Novus Biologicals Category Protein Species Human

HR6B/UBE2B Peptide - P0888 from Novus Biologicals Category Peptide Species Human

UBE2B-Antibody-Center-Blocking-Peptide - BP16790c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2B-Antibody-C-term-Blocking-Peptide - BP2115b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-HR6B/UBE2B, CF - E2-613-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant Human His6-HR6B/UBE2B, CF - E2-613-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

UBE2B Protein (OPPA00857) - OPPA00857 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human UBE2B protein - orb180450 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human HR6B protein - orb163495 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human Ubiquitin Conjugating Enzyme E2B protein - orb90293 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

UBE2B protein (His tag) - 80R-1333 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

UBE2B / RAD6B (1-152, His-tag) - AR09479PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

UBE2B / RAD6B (1-152, His-tag) - AR09479PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

UBE2B / RAD6B - H00007320-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE2B / RAD6B - H00007320-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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