| Gene Symbol | UBE2B |
|---|---|
| Entrez Gene | 7320 |
| Alt Symbol | E2-17kDa, HHR6B, HR6B, RAD6B, UBC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2B |
| Other Description | E2 protein|RAD6 homolog B|ubiquitin carrier protein B|ubiquitin-conjugating enzyme E2 B|ubiquitin-conjugating enzyme E2-17 kDa|ubiquitin-conjugating enzyme E2B (RAD6 homolog)|ubiquitin-protein ligase B |
| Swissprots | D3DQA2 Q9D0J6 Q4PJ15 P23567 P63146 B2R503 |
| Accessions | AAY68224 EAW62257 EAW62258 P63146 AK312012 BAG34950 BC001694 BC005979 AAH05979 BC008404 AAH08404 BC008470 AAH08470 BT007071 AAP35734 BU954901 CR407634 CAG28562 DA523817 DQ893113 ABM84039 DQ896387 ABM87386 M74525 AAA35982 T88933 X53251 CAA37339 NM_003337 NP_003328 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:1717990, ECO:0000269|PubMed:20061386}. |
| Subcellular Location | Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis |