TP53BP1

Gene Symbol	TP53BP1
Entrez Gene	7158
Alt Symbol	53BP1, p202, p53BP1
Species	Human
Gene Type	protein-coding
Description	tumor protein p53 binding protein 1
Other Description	p53-binding protein 1|tumor protein 53-binding protein, 1|tumor protein p53-binding protein, 1|tumor suppressor p53-binding protein 1
Swissprots	Q2M1Z7 Q7Z3U4 Q12888 Q5FWZ3 Q4LE46 F8VY86
Accessions	AAW69392 EAW92604 EAW92605 Q12888 AB210025 BAE06107 AF078776 AAC62018 AK123418 BAG53901 AK125173 AK292915 BAF85604 AK295764 BAH12183 AK307405 BC017846 AAH17846 BC063119 BC112161 AAI12162 BP228994 BX537418 CAD97660 U09477 AAA21596 XM_005254635 XP_005254692 XM_011521984 XP_011520286 XM_011521985 XP_011520287 XM_011521986 XP_011520288 XR_931898 XR_931899 NM_001141979 NP_001135451 NM_001141980 NP_001135452 NM_005657 NP_005648
Function	Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. {ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

53BP1 CRISPR/Cas9 KO Plasmid (h) - sc-400321 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 HDR Plasmid (h) - sc-400321-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 Double Nickase Plasmid (h) - sc-400321-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 Double Nickase Plasmid (h2) - sc-400321-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 CRISPR Activation Plasmid (h) - sc-400321-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 CRISPR Activation Plasmid (h2) - sc-400321-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 Lentiviral Activation Particles (h) - sc-400321-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 Lentiviral Activation Particles (h2) - sc-400321-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

53BP1 siRNA (h) - sc-37455 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

53BP1 shRNA Plasmid (h) - sc-37455-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

53BP1 shRNA (h) Lentiviral Particles - sc-37455-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

53BP1 RNAi - H00007158-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU156121 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21843 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21843 from Sigma-Aldrich Category ZFN Kit Prices $4,120.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00982 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00982

TP53BP1 siRNA (Human) - CRH4910 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TP53BP1 - MBS8223562 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TP53BP1 (NM_005657.2) - SHH433069 from Creative biogene Category siRNA Species Reactivities Human

Human TP53BP1 siRNA - orb265412 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TP53BP1 shRNA Plasmid (Human) - CHH4910 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TP53BP1 miRNA 3'UTR clone - MiUTR3H-07495 from Creative biogene Species Reactivities Human

TP53BP1 miRNA 3'UTR clone - MiUTR3H-07496 from Creative biogene Species Reactivities Human

TP53BP1 miRNA 3'UTR clone - MiUTR3H-07497 from Creative biogene Species Reactivities Human

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