TP53BP1

Gene Symbol TP53BP1
Entrez Gene 7158
Alt Symbol 53BP1, p202, p53BP1
Species Human
Gene Type protein-coding
Description tumor protein p53 binding protein 1
Other Description p53-binding protein 1|tumor protein 53-binding protein, 1|tumor protein p53-binding protein, 1|tumor suppressor p53-binding protein 1
Swissprots Q2M1Z7 Q7Z3U4 Q12888 Q5FWZ3 Q4LE46 F8VY86
Accessions AAW69392 EAW92604 EAW92605 Q12888 AB210025 BAE06107 AF078776 AAC62018 AK123418 BAG53901 AK125173 AK292915 BAF85604 AK295764 BAH12183 AK307405 BC017846 AAH17846 BC063119 BC112161 AAI12162 BP228994 BX537418 CAD97660 U09477 AAA21596 XM_005254635 XP_005254692 XM_011521984 XP_011520286 XM_011521985 XP_011520287 XM_011521986 XP_011520288 XR_931898 XR_931899 NM_001141979 NP_001135451 NM_001141980 NP_001135452 NM_005657 NP_005648
Function Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. {ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835}.
Subcellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

Phospho-53BP1 (Ser1618) (D4H11) Rabbit mAb - 6209 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4H11
Western blot analysis of extracts from HeLa cells, untreated (-) or synchronized in mitosis by thymidine block and release into nocodazole (+), using Phospho-53BP1 (Ser1618) (D4H11) Rabbit mAb (upper) or 53BP1 (P550) Antibody #4908 (lower).

Phospho-53BP1 (Ser1778) Antibody - 2675 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or UV-treated (50 mJ for 2 hours), using Phospho-53BP1 (Ser1778) Antibody (upper) or 53BP1 Antibody #4937 (lower).

Phospho-53BP1 (Thr543) Antibody - 3428 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from M059K cells, untreated or UV-treated, using Phospho-53BP1 (Thr543) Antibody (upper) or 53BP1 Antibody #4937 (lower).

Phospho-53BP1 (Ser25/29) Antibody - 2674 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or UV-treated (50 mJ for 2 hours), using Phospho-53BP1 (Ser25/29) Antibody (upper) or 53BP1 Antibody #4937 (lower).

53BP1 (P550) Antibody - 4908 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using 53BP1 (P550) Antibody.

53BP1 Antibody - 4937 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT29 cells, using 53BP1 Antibody.

53BP1 (H-300) - sc-22760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
53BP1 (H-300): sc-22760. Western blot analysis of 53BP1 expression in Sol8 (A) and Jurkat (B) whole cell lysates.

53BP1 (G-16) - sc-10915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
53BP1 (G-16): sc-10915. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing nuclear and cytoplasmic staining of respiratory epithelial cells.

53BP1 (F-19) - sc-10914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

53BP1 (D-20) - sc-10911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-53BP1 (Ser 1778) - sc-109897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-53BP1 (phospho S25) antibody - ab70323 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach carcinoma (left) and mouse teratoma (right) tissues labelling 53BP1 (phospho S24) with ab70323 at 1/1000 (1µg/ml). Detection: DAB.

Anti-53BP1 (phospho S25) antibody - ab82550 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab82550, at a 1:250 dilution, staining Human 53BP1 (phospho Ser25) in colon adenocarcinoma (mock phosphatase treated section), using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-53BP1 (phospho T1609 + S1618) antibody - ab191551 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-53BP1 (phospho T1609 + S1618) antibody (ab191551) at 1/1000 dilutionLane 1 : MEFs (negative control)Lane 2 : HeLa cell mitotic extract (positive control)Lane 3 : HeLa cell G1 extract (low phosphorylation)

Anti-53BP1 antibody - ab36823 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse renal cell carcinoma tissue labelling 53BP1 with ab36823 at 1/1000 (1µg/ml). Detection: DAB.

Anti-53BP1 antibody - ab21083 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-53BP1 antibody - ab172580 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells labelling 53BP1 with ab172580 at 1:1000. Cells were fixed with PFA and permeabilized with methanol for 2 minutes. Cells were incubated with the primary anitbody overnight at room temperature. Top - 53BP1, Middle - DAPI, Bottom - Merge.

Anti-53BP1 antibody - ab87097 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-53BP1 antibody (ab87097) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-53BP1 antibody - ab36828 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-53BP1 antibody (ab36828) at 1/2000 dilution + Whole cell lysate from human U205 cells at 20 µgdeveloped using the ECL technique

Anti-53BP1 antibody - ab100865 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-53BP1 antibody (ab100865) at 1/500 dilution + Human fetal brain lysate

Anti-53BP1 antibody - ab62626 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62626 at a 1/500-1/1000 dilution.Left image untreated.Right image treated with peptide.

Anti-53BP1 antibody [EPR2172(2)] - ab175933 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2172(2)
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using labeling 53BP1 with ab175933 at 1/100 dilution

Anti-53BP1 antibody [EPR2173(2)] - ab175188 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2173(2)
All lanes : Anti-53BP1 antibody [EPR2173(2)] (ab175188) at 1/50000 dilutionLane 1 : Human fetal heart lysatesLane 2 : HepG2 lysatesLane 3 : Human fetal brain lysatesLysates/proteins at 10 µg per lane.

Anti-TP53BP1 / 53BP1 Antibody (N-Terminus) - LS-C20110 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TP53BP1 / 53BP1 Antibody (aa1-337) - LS-C25828 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
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