| Gene Symbol | Camk4 |
|---|---|
| Entrez Gene | 12326 |
| Alt Symbol | A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase IV |
| Other Description | CAM kinase-GR|Ca2+/calmodulin-dependent protein kinase type IV/Gr|caMK IV|calcium/calmodulin-dependent protein kinase type IV |
| Swissprots | P08414 Q61381 |
| Accessions | EDK97068 EDK97069 P08414 AK030219 BAC26850 AK030817 AK040523 AK043114 BAC31462 AK043457 AK079904 AK148809 BC070420 AAH70420 CJ104330 J03057 AAA37366 M16206 AAA39933 M64266 AAA37364 X58995 CAA41741 XM_006525543 XP_006525606 XM_006525544 XP_006525607 XM_006525546 XP_006525609 XM_006525547 XP_006525610 XR_877121 NM_009793 NP_033923 |
| Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10932193}. Nucleus {ECO:0000269|PubMed:10932193}. Note=Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix. {ECO:0000250}. |
| Tissue Specificity | Expressed in brain and testis. {ECO:0000269|PubMed:10932193, ECO:0000269|PubMed:11951046}. |
| Top Pathways | cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction |