Tp53

Gene Symbol	Tp53
Entrez Gene	24842
Alt Symbol	Trp53, p53
Species	Rat
Gene Type	protein-coding
Description	tumor protein p53
Other Description	cellular tumor antigen p53|transformation related protein 53|tumor protein p53 (Li-Fraumeni syndrome)|tumor suppressor p53
Swissprots	Q4KMA9 O09168 Q66HM0 P10361
Accessions	AAA41788 AAF43277 AAF43278 AAG34052 AAG34053 EDM04871 EDM04872 EDM04873 P10361 AF209191 AAG35765 AY009504 AAG35178 BC081788 AAH81788 BC098663 AAH98663 CV126174 FQ232659 U90328 AAB80959 X13058 CAA31457 XM_006246594 XP_006246656 XM_006246595 XP_006246657 XM_008767773 XP_008765995 NM_030989 NP_112251
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to e
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:22726440}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways	Measles, Epstein-Barr virus infection, Sphingolipid signaling pathway, Apoptosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Rat p53 protein - orb245624 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Rat

Recombinant rat Cellular tumor antigen p53 protein - CSB-EP155094r CSB-BP155094r CSB-MP155094r from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Rat

Recombinant Rat Cellular tumor antigen p53(Tp53) - CSB-RP155094r from Cusabio Category Protein Source E.coli Species Rat

Recombinant Rat Cellular tumor antigen p53(Tp53) - CSB-YP024077RA CSB-EP024077RA CSB-BP024077RA CSB-MP024077RA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Rat

Cellular tumor antigen p53 protein - RPC140319 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Rat

Cellular tumor antigen p53 (Tp53), Recombinant Protein - MBS1073718 from MyBioSource Category Protein Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,860.00, $1,860.00, $2,325.00, $2,325.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Rat

Recombinant Rat TP53 Protein - TP53-6230R from Creative Biomart Category Protein Source Mammalian Cells Species Rat

Recombinant Rat Cellular tumor antigen p53(Tp53) - RPC20212 from Biomatik Category Protein Prices $106.00, $242.00, $380.00, $594.00, $945.00, $1,424.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Rat

TP53 Recombinant Protein (OPCD07651) - OPCD07651 from Aviva Systems Biology Category Protein Source E.coli Species Rat

Recombinant rat Cellular tumor antigen p53 protein - AP72290 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Rat

Cellular tumor antigen p53, Recombinant Protein - MBS9422041 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Rat

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