Tp53

Gene Symbol	Tp53
Entrez Gene	24842
Alt Symbol	Trp53, p53
Species	Rat
Gene Type	protein-coding
Description	tumor protein p53
Other Description	cellular tumor antigen p53|transformation related protein 53|tumor protein p53 (Li-Fraumeni syndrome)|tumor suppressor p53
Swissprots	Q4KMA9 O09168 Q66HM0 P10361
Accessions	AAA41788 AAF43277 AAF43278 AAG34052 AAG34053 EDM04871 EDM04872 EDM04873 P10361 AF209191 AAG35765 AY009504 AAG35178 BC081788 AAH81788 BC098663 AAH98663 CV126174 FQ232659 U90328 AAB80959 X13058 CAA31457 XM_006246594 XP_006246656 XM_006246595 XP_006246657 XM_008767773 XP_008765995 NM_030989 NP_112251
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to e
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:22726440}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways	Measles, Epstein-Barr virus infection, Sphingolipid signaling pathway, Apoptosis, Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

p53 (phospho Ser392) antibody - GTX23257 from GeneTex Prices $319.00 Sizes 100 μl Host Rabbit Clonality Polyclonal

TP53 Antibody (OACA02085) - OACA02085 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TP53 Antibody (OACA02086) - OACA02086 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TP53 Antibody (OACA02087) - OACA02087 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TP53 Antibody (OACA02088) - OACA02088 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

p53 antibody - 70R-15485 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

p53 antibody (FITC) - 60R-2273 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

p53 antibody (biotin) - 60R-2274 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

p53 antibody (HRP) - 60R-2272 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53 Antibody - abx110393 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53 Antibody (Biotin) - abx106114 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53 Antibody (FITC) - abx107528 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53 Antibody (HRP) - abx108947 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

TP53 / p53 pSer392 antibody - AP08718PU-N from Acris Antibodies Prices $350.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53, Polyclonal Antibody - MBS719805 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53, Polyclonal Antibody - MBS719659 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53, Polyclonal Antibody - MBS719426 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Cellular tumor antigen p53, Polyclonal Antibody - MBS719724 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Tp53 Antibody,Biotin conjugated - CSB-PA15509D0Rb from Cusabio Host Rabbit Clonality Polyclonal

Tp53 Antibody,HRP conjugated - CSB-PA15509B0Rb from Cusabio Host Rabbit Clonality Polyclonal

Tp53 Antibody,FITC conjugated - CSB-PA15509C0Rb from Cusabio Host Rabbit Clonality Polyclonal

Tp53 Antibody - CSB-PA15509A0Rb from Cusabio Host Rabbit Clonality Polyclonal

anti-p53 antibody [Pab1801] - ARG10519 from Arigo Biolaboratories Host Mouse Clonality Monoclonal Clone Pab 1801

anti-p53 phospho (Ser392) antibody - ARG52383 from Arigo Biolaboratories

anti-P53 phospho (Ser15) antibody - ARG20150 from Arigo Biolaboratories

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